Gene
hcn2b
- ID
- ZDB-GENE-030131-8228
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 2b
- Symbol
- hcn2b Nomenclature History
- Previous Names
-
- hcn2
- si:dkey-28h18.1
- wu:fj61d07
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated potassium channel activity. Acts upstream of or within swimming behavior. Predicted to be located in plasma membrane. Predicted to be part of HCN channel complex. Predicted to be active in axon and dendrite. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Rodríguez-Ortiz et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hcn2b | Rodríguez-Ortiz et al., 2021 | |
| CRISPR2-hcn2b | Rodríguez-Ortiz et al., 2021 | |
| CRISPR3-hcn2b | Rodríguez-Ortiz et al., 2021 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial febrile seizures 2 | Alliance | Febrile seizures, familial, 2 | 602477 |
| familial febrile seizures 2 | Alliance | Generalized epilepsy with febrile seizures plus, type 11 | 602477 |
| familial febrile seizures 2 | Alliance | {Epilepsy, idiopathic generalized, susceptibility to, 17} | 602477 |
1 - 3 of 3
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG-like |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium channel, voltage-dependent, EAG/ELK/ERG-like | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T6V3
|
979 | ||||||||
|
UniProtKB:A0A8M3B5M0
|
538 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28H18 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-74C5 | ZFIN Curated Data | |
| Encodes | EST | fj61d07 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_680322 (1) | 3534 nt | ||
| Genomic | GenBank:BX664631 (1) | 220242 nt | ||
| Polypeptide | UniProtKB:A0A8N7T6V3 (1) | 979 aa |
- Rodríguez-Ortiz, R., Matínez-Torres, A. (2021) Mutants of the Zebrafish K+ Channel Hcn2b Exhibit Epileptic-like Behaviors. International Journal of Molecular Sciences. 22(21):
- von der Heyde, B., Emmanouilidou, A., Mazzaferro, E., Vicenzi, S., Höijer, I., Klingström, T., Jumaa, S., Dethlefsen, O., Snieder, H., de Geus, E., Ameur, A., Ingelsson, E., Allalou, A., Brooke, H.L., den Hoed, M. (2020) Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. Scientific Reports. 10:11831
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Trapani, J.G., and Nicolson, T. (2011) Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(5):1614-1623
1 - 6 of 6
Show