J Infect Dis. October 28, 2024
Impact of Dolutegravir plus Lamivudine as First-Line Antiretroviral Treatment on HIV-1 Reservoir and Inflammatory Markers in Peripheral Blood

Cancers (Basel). October 19, 2024
Functional Targets for Epstein-Barr Virus BART MicroRNAs in B Cel Lymphomas

Proc Natl Acad Sci USA. October 15, 2024
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.

Sci Immunol. October 11, 2024
Human cytomegalovirus UL18 prevents priming of MHC-E- and MHC-II-restricted CD8+ T cells.

Microbiol Spectr. September 30, 2024
Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

Mabs. September 26, 2024
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

BioDrugs. September 18, 2024
Chikungunya Virus Vaccines: A Review of IXCHIQ and PXVX0317 from Pre-Clinical Evaluation to Licensure

Nat Immunol. September 12, 2024
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

mBio. September 6, 2024
Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2

Cell. September 5, 2024
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Cell. September 5, 2024
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype

Journal of Virology. August 2024
Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins

J Virol. August 29, 2024
A nanobody interaction with SARS-COV-2 Spike allows the versatile targeting of lentivirus vectors

JCI Insight. August 27, 2024
Immune perturbation following SHIV infection is greater in newborn macaques than in infants

Vaccines (Basel). August 27, 2024
Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

PLoS Pathog. August 22, 2024
Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence

Science. August 9, 2024
Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates

JCI Insight. August 8, 2024
Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates

PLoS Pathog. August 8, 2024
HIV transcription persists in the brain of virally suppressed people with HIV

Vaccines, August 2024
The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Frontiers in Immunology, August 2024
Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques

Nat Commun. July 19, 2024
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Cell. July 18, 2024
Analysis of the diverse antigenic landscape of the malaria protein RH5identifies a potent vaccine-induced human public antibody clonotype

Cell. July 17, 2024
Natural Malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

PLoS Pathog. June 17, 2024
MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation

ACS Infect Dis. June 11, 2024
3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance

Emerg Infect Dis. June 2024
Evaluating Humoral Immunity Elicited by XBB.1.5 Monovalent COVID-19 Vaccine

Elife. May 28, 2024
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

bioRxiv. May 24, 2024
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice

Malar J. May 23, 2024
Evaluation of naturally acquired immune responses against novel pre-erythrocytic Plasmodium vivax proteins in a low endemic malaria population located iun the Peruvian Amazon Basin

J Virol. May 22, 2024
Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection

bioRxiv. May 21, 2024
Viral and host network analysis of the human cytomegalovirus transcriptome in latency

bioRxiv. May 15, 2024
Trifunctional fatty acid derivatives demonstrate the impact of diazirine placement

Sci Adv. May 10, 2024
CD8+ T cell targeting of tumor antigens presented by HLA-E

Vaccine. April 11, 2024
Effectiveness of a bivalent mRNA vaccine dose against symptomatic SARS-CoV-2 infection among U.S. Healthcare personnel, September 2022-May 2023

PLoS Pathog. April 9, 2024
Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

J Clin Invest. April 1, 2024
Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers

bioRxiv [Preprint] March 22, 2024
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

Front Immunol. March 20, 2024
The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E

J Transl Med. March 19, 2024
Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques

J Virol. March 19, 2024
Correction for Rasmussen et al., "Virology-the path forward"

mBio. March 13, 2024
Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques

bioRxiv Feb 28, 2024
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

bioRxiv Feb 28, 2024
Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

Commun Biol. Feb 24, 2024
Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

Viruses Feb 15, 2024
SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo

Viruses Feb 1, 2024
High-Throughput Screening for the Prevalence of Neutralizing Antibodies against Human Adenovirus Serotype 5

J Virol. Jan 23, 2024
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bioRxiv. Jan 15, 2024
MicroRNA-focused CRISPR/Cas9 Screen Identifies miR-142 as a Key Regulator of Epstein-Barr Virus Reactivation

NPJ Vaccines. Jan 10, 2024
Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

J Clin Invest. Jan 2024
Contralateral second dose improves antibody responses to a two-dose mRNA vaccination regimen

Hum Gene Ther. Dec 2023
Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures

Front Immunol. Nov 2023
Corrigendum: Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

PLoS Negl Trop Dis. Nov 20^th, 2023
Mayaro virus pathogenesis and immunity in rhesus macaques

Nat Commun. November 3^rd, 2023
Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

J Virol. October 31^st, 2023
HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34+ hematopoietic progenitor cells

Front Immunol. October 26^th, 2023
Marked Skewing of entire T-cell memory compartment occurs only in a minority of CMV-infected individuals and is unrelated to the degree of memory subset skewing among CMV-specific T-cells

Nat Commun. October 23^rd, 2023
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir

PLoS Pathog, October 23^rd, 2023
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in rhesus macaque model

PLoS Pathog, October 6^th, 2023
Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication

PLoS Pathog, October 5^th, 2023
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

Front Immunol. October 3^rd, 2023
Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

PLoS Pathog. October 2^nd 2023
Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation

Am J Reprod Immunol. October 2023
Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques

Ann Neurol. October 2023
Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

J Virol. September 29, 2023
HCMV UL8 interaction with β-catenin and DUL2 regulates viral reactivating in CD34+ hematopoietic progenitor cells

ACS ES T Water. September 27, 2023
Community-Based SARS-CoV-2 Testing Using Saliva or Nasopharyngeal Swabs to Compare the Performance of Weekly Covide-19 Screening to Wastewater SARS-CoV-2 Signals

Cell Host Microbe. September 13, 2023
Spontaneous HIV expression during suppressive ART in associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells

J Virol. August 31, 2023
Stabilization of the human cytomegalovirus UL136p33 reactivation determinant overcomes the requirement for UL135 for replication in hematopoietic cells

Front Immunol. August 22, 2023
Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Macaca fascicularis)

Sci Immunol. July 28, 2023
Modulation of type I interferon responses protently inhibits SARS-CovV-2 replication and inflammation in rhesus macaques

Ann Neurol. July 23, 2023
Regional analysis of intact and defective HIV proviruses in the brain of viremic and virally suppressed people with HIV

Rheumatol Immunol Res. July 22, 2023
mRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis

Immunity. July 11, 2023
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

bioRxiv. June 16, 2023
The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

PLoS Pathog. June 8, 2023
Human Cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection

J Virol. May 23, 2023
Lymph-Node-Based CD3+ CD20+ cells emerge from membrane exchange between T Follicular Helper Cells and B Cells and increase their frequency following Simian Immunodeficiency Virus infection

Proc Natl Acad Sci USA. May 16, 2023
Complement contributes to antibody-medicated protection against repeated SHIV challenge

Immunity. May 13, 2023
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

Int J Mol Sci. May 5, 2023
A Multifunctional and Highly Adaptable Reporter System for CRISPR/Cas Editing

mBio. April 25, 2023
Evidence for the role of a second Fc-Binding receptor in placental IgG Transfer in Nonhuman Primates

bioRxiv. April 21, 2023
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

PLoS Pathog. April 19, 2023
Correction: mitigation of endemic GI0tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

bioRxiv. April 17, 2023
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to entry inhibitor Temsavir

bioRxiv. April 10^th, 2023
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

Sci Transl Med. March 29, 2023
Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection

PLoS Pathog. March 29^th, 2023
Chronic immune activation and gut barrier dysfunction in associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

mBio. March 22^nd, 2023
Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates

PLoS Negl Trop Dis. March 13^th, 2023
Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominately through the B domain of the E2 glycoprotein

JCI Insight. March 8^th, 2023
An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants

Trends Immunol. March 7^th, 2023
Programming cytomegalovirus as an HIV vaccine

mBio. February 28^th, 2023
Virology under the microscope-a call for rational discourse

mBio. February 22^nd, 2023
Advances in model systems for human Cytomegalovirus latency and reactivation

Nat Commun. February 22^nd, 2023
Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys

Nat Med. February 20^th, 2023
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

JCI Insight. February 7^th, 2023
Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV

JCI Insight. January 23^rd, 2023
An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants

Brain Behav Immun. January 19^th, 2023
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease

Commun Biol. December 19^th, 2022
Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines

Stem Cell Reports. December 13^th, 2022
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

Semin Cell Dev Biol. November 30^th, 2022
Viral miRNA regulation of host gene expression

NPJ Vaccines. November 4^th, 2022
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver.

Cell Rep. October 25^th, 2022
BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age.

bioRxiv. October 24^th, 2022
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.

Stem Cell Reports. October 18^th, 2022
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques.

EBioMedicine. October 2022
Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Curr Opin Virol. October 12^th, 2022
MicroRNA-mediated control of Epstein-Barr virus infection and potential diagnostic and therapeutic implications

Psychosom Med. October 1^st, 2022
Individual differences in CD4/CD8 T-cell ratio trajectories and associated risk profiles modeled from acute HIV infection

Clin Infect Dis. September 30^th, 2022
Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome

Comp Med. September 26^th, 2022
Effects of Early Antiretroviral Therapy on the Composition and Diversity of the Fecal Microbiome of SIV-infected Rhesus Macaques (Macaca mulatta)

Med (NY). September 22^nd, 2022
Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection

PLoS Pathog. September 19, 2022
The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors

J Immunol. September 19, 2022
Novel lymphocytic choriomeningitis virus strain sustains abundant exhausted progenitor CD8 T cells without systemic Viremia

Med (NY). September 9, 2022
Acute HIV-1 infection viremia associate with rebound upon treatment interruption

Viruses. September 9^th, 2022
Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders

EbioMedicine. September 8, 2022
Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Psychosom Med. September 6^th, 2022
Individual differences in CD4/CD8 T-cell ratio trajectories and associated risk profiles modeled from acute HIV infection

Cell Host Microbe. August 12, 2022
Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species

J Virol. August 4, 2022
Pandemic 1918 influenza virus does not cause lethal infection in rhesus or cynomolgus macaques

Ann Neurol. July 22, 2022
Intact HIV proviruses persist in the brain despite viral suppression with ART

Med (N Y). July 20, 2022
Acute HIV-1 infection viremia associate with rebound upon treatment interruption

Antimicrob Agents Chemother. July 20, 2022
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates

J Med Primatol. July 15, 2022
Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta)

PLoS Pathog, July 5, 2022
Development of a next-generation chikungunya virus vaccine based on the HydroVax platform

Curr Opin HIV AIDS, July 1, 2022
CD8+ T-cell responses in HIV controllers: potential implications for novel HIV remission strategies

Sci Immunol. June 17, 2022
Myeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine

Sci Rep. June 16, 2022
CRISPR/Cas9 editing of the MYO7A gene in rhesus macaque embryos to generate a primate model of Usher syndrome type 1B

J Clin Invest. June 1, 2022
Transforming dysfunctional CD8+ T cells into natural controller-like CD8+ T cells: can TCF-1 be the magic wand?

Nature Comm. May 30, 2022
Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity

NPJ Vaccines. May 26, 2022
Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozite infection and may enhance protection of anti0CSP monoclonal antibodies

Bioinformatics. May 13, 2022
BFF and cellhashR: analysis tools for accurate demultiplexing of cell hashing data

Mol Ther. May 4, 2022
Monoclonal antibodies for malaria prevention

J int AIDS Soc. April 25, 2022
Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent

PLoS One. April 20, 2022
Antimicrobial prophylaxis does not improve post-surgical outcomes in SIV/SHIV-uninfected or SIV/SHIV-infected macaques (Macaca mulatta and Macaca fascicularis) based on a retrospective analysis

J Clin Invest. April 15, 2022
Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy

J Infect Dis. April 13, 2022
De-risking human cytomegalovirus vaccine clinical development in relevant preclinical modelsImmunity.

Immunity. April 12, 2022
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments

PLoS Pathog. April 8, 2022
Ad26.COV2.S prevents upregulation of SARS-CoV02 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques

PLoS Pathog. March 31, 2022
Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species

Antiviral Res. March 23, 2022
Therapeutic and prophylactic treatment with a virus-specific antibody is highly effective in rodent models of Chikungunya infection and disease

J Clin Invest. March 22, 2022
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy

J Virol. Feb 23, 2022
Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3'UTR and Regulates the Lytic Cycle

Cell Rep. Feb, 2022
Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination

Nat Commun. Feb 15, 2022
Differential V2-directed antibody responses in non-human primates infected with diverse HIV vaccines

Nat Commun. Feb 3, 2022
Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

J Immunol Methods. Feb, 2022
Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue

JCI Insight. Feb, 2022
IFNα-blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health

PLoS Pathog. Jan 18, 2022
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

JAMA. Jan 11, 2022
Antibody response and variant cross-neutralization after SARS-CoV-2 breakthrough infection

mBio. Jan 11, 2022
Advances in model systems for human cytomegalovirus latency and reactivation

Open Forum Infect Dis. Dec, 2021
A Randomized, Placebo-Controlled Trial Assessing the Effect of VISBIOME ES Probiotic in People With HIV on Antiretroviral Therapy

J Immunol. Nov 22, 2021
Identification and Characterization of Antigen-Specific CD8 + T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing

Front Immunol. Nov 19, 2021
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

J Clin Invest. Nov 11, 2021
Anti-HIV antibody development up to one year after antiretroviral therapy initiation in acute HIV infection

Viruses, Oct 16, 2021
Nonhuman Primate Models of Zika Virus Infection and Disease during Pregnancy

Am J Primatol. Sep 20, 2021
Improving rigor and reproducibility in nonhuman primate research

Mol Ther Methods Clin Dev. Sep 10, 2021
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques

Microbiol Spectr. September 3, 2021
Comparison of SARS-CoV-2 PCR-Based Detection Using Saliva or Nasopharyngeal Swab Specimens in Asymptomatic Populations

PLoS Pathog. August 19, 2021
Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

PLoS Pathog. July 20, 2021
Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques

Curr Opin HIV AIDS. July 1, 2021
Eliminating HIV reservoirs for a cure: the issue is in the tissue

AAC. June 21, 2021
Identification of Quinolinones as Antivirals Against Venezuelan Equine Encephalitis Virus

Nature. June 7, 2021
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

Brain Behav Immun Health. May 2021
The role of oxidative stress in HIV-associated neurocognitive disorders

PLoS Pathog. May 10, 2021
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

Front Microbiol. May 7, 2021
Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

mSphere. April 14, 2021
B Cell Receptor-Responsive MiR-141 enhances Epstein-Barr virus lytic cycle via FOXO3 inhibition

J Med Chem. April 9, 2021
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors

PLoS Negl Trop Dis. April 1, 2021
Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses

mBio. March 30, 2021
Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus

Sci Immunol. March 25, 2021
Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

Science. March 25, 2021
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

Sci Immunol. March 25, 2021
HLA-E-restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities

Eur J Nucl Med Mol Imaging. March 18, 2021
Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker

Cell Host Microbe. March 5, 2021
TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

J Clin Invest. February 25, 2021
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification

Front Immunol. February 15 2021
Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

Pathogens. February 13, 2021
Regulation of Latency and Reactivation by Human Cytomegalovirus miRNAs

Virology. February 9, 2021
Rat and human cytomegalovirus ORF116 encodes a virion envelope glycoprotein required for infectivity

Methods Mol Biol. February 9, 2021
Techniques for Characterizing Cytomegalovirus-Encoded miRNAs

Methods Mol Biol. February 9, 2021
Antibody-Independent Quantification of Cytomegalovirus Virion Protein Incorporation Using HiBiT

J Virol. February 3, 2021
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo

Open Forum Infect Dis. February 2, 2021
Establishment of Monoclonal Antibody Standards for Quantitative Serological Diagnosis of SARS-CoV-2 in Low-Incidence Settings

PLoS One. January 22, 2021
Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design

Am J Transplant. January 21, 2021
Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection

J Leukoc Biol. January 19, 2021
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

Ann Clin Transl Neurol. January 13, 2021
Myelin-specific T cells in animals with Japanese macaque encephalomyelitis

J Transl Autoimmun. January 6, 2021
Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab

J Virol. December 16, 2020
Membrane-associated and secreted forms of the Rhesus macaque Rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 receptor signaling and regulation of myeloid cell activation

PLoS Pathog. November 24, 2020
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

PLoS Pathog. November 19, 2020
Rat cytomegalovirus virion-associated proteins R131 and R129 are necessary for infection of macrophages and dendritic cells

Transpl Infect Dis. November 18, 2020
Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection

J Virol. November 11, 2020
CD34+ hematopoietic progenitor cell subsets exhibit differential ability to maintain HCMV latency and persistence

Cell. November 10, 2020
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Int J Infect Dis. November 10, 2020
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

Cell Host Microbe. October 27, 2020
Ultra-low dose aerosol infection of mice with Mycobacterium tuberculosis more closely models human tuberculosis

Clin Infect Dis. October 20, 2020
Clinical characteristics and outcomes of COVD-19 patients receiving compassionate use Leronlimab

Cell. October 9, 2020
Vascular disease and thrombosis in SARS-CoV-2-infected rhesus macaques

J Clin Apher. September 17, 2020
Terumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection

Abdom Radiol (NY). September 17, 2020
Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients

bioRxiv. September 16, 2020
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Nat Med. September 7, 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials

Nat Med. September 3, 2020
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Front Immunol. August 12, 2020
Rhesus cytomegalovirus-specific CD8+ cytotoxic T lymphocytes do not become functionally exhausted in chronic SIVmac239 infection

mSphere. August 5, 2020
Human Cytomegalovirus miR-US5-2 downregulation of GAB1 regulates cellular proliferation and UL138 expression through modulation of epidermal growth factor receptor signaling pathways

Antiviral Res. August 3, 2020
Animal models for the study of human hepatitis B and D virus infection: New insights and progress

J Immunol. August 1, 2020
CTL clonotypes with higher TCR affinity have better ability to reduce the HIV latent reservoir

Front Cell Infect Microbiol. July 31, 2020
The differentiation of human Cytomegalovirus infected-monocytes in required for viral replication

Front Immunol. July 8, 2020
Characterization of a novel compound that stimulates STING-mediated innate immune activity in an Allele-specific manner

Front Immunol. June 2, 2020
Rapid Induction of multifunctional antibodies in rabbits and macaques by Clade C HIV-1 CAP257 envelopes circulating during epitope-specific neutralization breadth development

OHSU, May 22, 2020
Coronavirus survivors could be protected against future illness, study suggests

Science, May 20, 2020
SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Methods Mol Biol, 2020
Analysis of Serum Anti-Zika Virus Antibodies by Focus Reduction Neutralization Test.

Methods Mol Biol, 2020
Isolation and Detection of Zika Virus-Infected Rhesus Macaques Lymph Node Cells and Splenocytes.

J Immunol, May 6, 2020
Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing.

medRxiv. May 5, 2020
Disruption of the CCL5/RANTES-CCR5 pathway restores immune homeostasis and reduces plasma viral load in critical COVID-19

Nat Med, April 26, 2020
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.

mBio, April 21, 2020
Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS.

J Immunol. April 15, 2020
MHC-E-Restricted CD8+ T Cells Target Hepatitis B Virus-Infected Human Hepatocytes.

Microorganisms, April 6, 2020
Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice.

J Virol, March 31, 2020
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PLoS Pathog. March 12, 2020
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.

PLoS Pathog. March 2, 2020
African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

PLoS One. February 26, 2020
Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1

Nat Immunol. February 17, 2020
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

Front Microbiol. February 14, 2020
The E3 ubiquitin ligase SIAH1 targets MyD88 for proteasomal degradation during Dengue Virus infection

PLoS One, February 4, 2020
Molecular analysis of lymphoid tissue from rhesus macaque Rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis

Curr Top Microbiol Immunol, January 24, 2020
Small molecule inhibitors targeting Chikungunya virus

Nature, January 22, 2020
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

PLoS One, January 14, 2020
A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

Xenotransplantation, January 13, 2020
Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications

Cell Host Microbe, January 8, 2020
Human Cytomegalovirus miRNAs Regulate TGF- β to mediate myelosuppression while maintaining viral latency in CD34+ hematopoietic progenitor cells

Nat Commun, January 7, 2020
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

HSU. December 19, 2019
Dangerous bone marrow, organ transplant complication explained

Cell Rep. November 19, 2019
Defects in antiviral T cells responses inflicted by aging-associated miR-181a deficiency

PLoS Pathog. November 14, 2019
HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

PLoS Pathog. November 14, 2019
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency

Front Immunol. October 31, 2019
Vaccine-induced skewing of T cell responses protects against Chikungunya virus disease

J Immunol. October 25, 2019
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PLoS Pathog. October 18, 2019
Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

J Infect Dis. October 16, 2019
Zika virus causes acute and chronic prostatitis in mice and macaques

J Virol. October 9, 2019
In vivo validation of the viral barcoding of SIVmac239 and the development of new barcoded SIV and subtype B and C SHIVs.

Vaccine, October 16, 2019
Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine

The Oregonian, September 21, 2019
OHSU doc dreams of lifetime immunity with one flu shot

Mucosal Immunol, September 3, 2019
Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfuction

Nat Commun, September 2, 2019
Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

MBio, August 20, 2019
Human Cytomegalovirus US28 ligand binding activity is required for latency in CD34+ hematopoietic progenitor cells and humanized NSG mice

Malar J. August 17, 2019
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J Exp Med, August 14, 2019
Risk of Zika microcephaly correlates with features of maternal antibodies

Curr Top Microbiol Immunol, July 24, 2019
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Sci Transl Med, July 17, 2019
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

J Virology, July 17, 2019
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Sci Transl Med, July 17, 2019
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

OHSU, July 17, 2019
HIV vaccine nears clinical trial following new findings

ACS Infect Dis, July 11, 2019
Studies on dibenzylamines as inhibitors of Venezuelan equine encephalitis virus

Cell Host Microbe, July 10, 2019
The landscape of persistent viral genomes in ART-Treated SIV, SHIV, and HIV-2 infections

EbioMedicine, July 9, 2019
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Sci Transl Med, July 3, 2019
Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

PNAS, April 2, 2019
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism

AAC, March 27, 2019
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The Scribe, March 2019
OHSU institute expands vaccine research to malaria

Front Immunol, March 22, 2019
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PLoS Pathog, March 7, 2019
Neissaria gonorrhoeae MIaA influences gonococcal virulence and membrane vesicle production

J Virol. March 5, 2019
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PNAS, Feb 26, 2019
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PLoS Pathog, February 21, 2019
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MBio, February 12, 2019
Human Cytomegalovirus immediate early 86-kDa protein blocks transcription and
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Journal of Virology, January 9, 2019
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PLoS Pathog, January 7, 2019
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Journal of Virology, October 17, 2018
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Nature Communications, September 27, 2018
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Current Opinion in Immunology, September 13, 2018
Corrigendum to 'Unusual antigen presentation offers new insight into HIV vaccine 
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Journal of Virology, August 29, 2018
Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in 
Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

Nature Communications, August 7, 2018
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket 
tolerability and conformationally malleable peptide binding

Nature Medicine, August 6, 2018
Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound 

Nature Medicine, July 30, 2018
Experimental Microbial dysbiosis does not promote disease progression in 
SIV-infected macaques

PLOS, July 12, 2018
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experimentally infected with SIV or SHIV

J. Virology, July 11, 2018
SIV persistence in cellular and anatomic reservoirs in ART-suppressed infant 
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Nat Med, July 2, 2018
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Front Immunol, June 18, 2018
Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular 
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Mucosal Immunol, June 15, 2018
Intestinal damage precedes mucosal immune dysfunction in SIV infection

Antiviral Research, April 27, 2018
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Nature Reviews Immunology, March 19, 2018
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Molecular Cancer Therapeutics, March 15, 2018
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P
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Frontiers In Immunology, March 6, 2018
In Utero Administration of Drugs Targeting Microglia Improves
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J. Virology, February 26, 2018
Antagonism of the protein kinase R pathway in human cells by rhesus 
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Blood Advances, January 23, 2018
The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into 
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Nature Medicine, January 15, 2018
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Retrovirology, January 9, 2018
Next-generation in situ hybridization approaches to define and quantify HIV and 
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J. Virology, January 2, 2018
Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral 
Burden after Heterologous Clade C SHIV Mucosal Challenge

J. Virology, January 1, 2018
The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus 
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Nature Communications, December 15, 2017
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide 
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Nature Communications, November 10, 2017
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PLOS, November 9, 2017
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Modulation of the NFkb Signalling Pathway by Human Cytomegalovirus

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Springer, July 4, 2017
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PLOS, June 19, 2017
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Scientific Reports, April 20, 2017
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Front Microbiology, April 3, 2017
The Heme Metabolite Carbon Monoxide Facilitates KSHV Infection by Inhibiting 
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PLOS, March 9, 2017
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Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block 
Proinflammatory Cytokine Production in Response to NF-kB-Activating Factors 
through Direct Downregulation of IKKa and IKKB

Journal of Virology, February 1, 2017
A microRNA screen identifies the Wnt signaling pathway as a regulator of the 
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American Society for Cell Biology, January 1, 2017
p120-catenin regulates VE-cadherin endocytosis and degradation induced by the 
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PLOS, December 15, 2016
Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized 
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PLOS, December 7, 2016
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The Journal of Infectious Diseases, December 5, 2016
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Nature Communications, November 30, 2016
Additives for vaccine storage to improve thermal stability of adenoviruses from 
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eLife, November 22, 2016
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Methods in Molecular Biology, November 22, 2016
Analysis of Viral and Cellular MicroRNAs in EBV-Infected Cells

PLOS, November 9, 2016
Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Immunity, October 18, 2016
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist 
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Mucosal Immunology - Nature, October 19, 2016
MR1-restricted Mucosal-associated invariant T (MAIT) cells respond to 
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Journal of Virology, October 15, 2016
Japanese Macaque Rhadinovirus Encodes a Viral MicroRNA Mimic of the miR-17 
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PLOS, October 13, 2016
Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to 
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A new perspective of the structural complexity of HCMV-specific T-cell responses

PLOS, August 31, 2016
Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

The Journal of Immunology, August 15, 2016
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PLOS, July 29, 2016
Cytomegalovirus Infection of the Rat Developing Brain In Utero 
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PLOS, June 2, 2016
Humans Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

The Journal of Immunology, April 1, 2016
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Nature, March 21, 2016
Early short-term treatment with neutralizing human monoclonal antibodies halts 
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American Society for Microbiology, March 1, 2016
Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and 
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Science, January 21, 2016
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Journal of Immunology, September 28, 2015
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American Society For Microbiology, June 4, 2015
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PLOS Pathogens, May 14, 2015
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Nature, January 19, 2015
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