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Led by Dr. Hong-Wei Sun, the Biodata Mining and Discovery Section facilitates biomedical research to support NIAMS IRP scientists and their discoveries.
Clinical Care and Research at NIAMS is located at the National Institutes of Health (NIH) campus in Bethesda, Maryland, comprises several programs of research focused on rheumatological health in minority and underserved populations. Medical experts in the fields of autoimmunity, arthritis, lupus, and other rheumatological diseases conduct research focused on the evaluation, diagnosis, standard of care, and disease management of underserved patients from the local community (Maryland, Virginia, and District of Columbia).
Led by Dr. Isaac Brownell, the Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate the development and maintenance of normal skin and the changes in these signals that occur during the formation of skin cancer
Led by Keisuke (Chris) Nagao, the section investigates cellular and molecular mechanisms that regulate immunological and structural homeostasis in the skin.
Led by Heidi Kong, the section uses genomics to study the skin microbes in healthy individuals and patients with skin diseases and to expand our understanding of host-microbe interactions.
The Dermatology Branch conducts both clinical and basic research studying the etiology, diagnosis, and treatment of inflammatory and malignant diseases involving the skin and the host's response to these diseases.
The Dermatology Consultation Service at the NIH Clinical Center evaluates patients with a variety of rare diseases with cutaneous manifestations. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are evaluated and treated. Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country receive training on the Dermatology consult service.
The Functional Immunogenomics Unit applies cutting-edge genomic technologies to the solution of medically important questions related to the immune system. A major focus is on the molecular dissection of the immunoregulatory effects of glucocorticoids.
The Genomic Technology Section helps NIAMS investigators solve highly diverse biological and biomedical research questions by providing a diverse portfolio of sequencing services as well as consultation and training for researchers with specific needs or challenging problems. It is a state-of-the-art laboratory facility equipped with the latest DNA sequencing and library preparation technologies.
Led by Dr. Hanna Kim, this unit studies juvenile myositis, including juvenile dermatomyositis, by comprehensively evaluating patients to better understand disease pathogenesis and conducting early phase clinical trials to evaluate new treatments.
Led by Dr. Naoko Mizuno, the Laboratory of Structural Cell Biology aims to understand the molecular mechanisms governing specialized cell shapes, such as those of neurons, activated immune cells or platelets and certain cancer cells.
Led by Dr. Sarfaraz Hasni, the unit studies the natural history and pathogenesis of lupus and involved in designing and conducting early phase clinical trials.
Led by Dr. Sarfaraz Hasni, the unit studies the natural history and pathogenesis of lupus and involved in designing and conducting early phase clinical trials.
Dr. Lewandowski leads a team of scientists studying systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.
The Transcriptional Regulation of Lymphocytes Unit focuses on the mechanisms behind T Cell specification. We integrate several next-generation sequencing techniques, such as RNAseq, to look at differential gene expression and ATACseq, to investigate T cell specification at both the transcriptional and epigenetic levels.
The focus of Dr. Glancy’s muscle energetics research program is to determine how mitochondria are optimized within muscle cells to help maintain energy homeostasis during the large change in energy demand caused by muscle contraction.
The Office of Science and Technology (OST) is responsible for the NIAMS Labs core facilities. It provides and develops new technologies and advises the Scientific Director, Lab and Section Chiefs, and researchers on emerging science and technology.
Led by Paul Wingfield, Ph.D., the Protein Expression Laboratory supports NIH research projects by analyzing and providing HIV proteins to their researchers and scientists.
Led by Dr. Markus Hafner, the laboratory studies the makeup of ribonucleoproteins (RNPs) involved in cellular RNA transport and control of RNA stability.
The Scleroderma Genomics and Health Disparities Unit is focused on unraveling genetic risk by using genomic technologies and dissecting the mechanisms of transcriptional regulation in order to comprehend autoimmune, fibrotic, and health disparity conditions.
The Translational Immunology Section provides NIAMS researchers with cutting-edge immune monitoring technology as they strive to develop accurate and reproducible immune monitoring assays.