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Review
. 2023 Mar 14;9(1):100322.
doi: 10.1016/j.jve.2023.100322. eCollection 2023 Mar.

Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection

Wen-Ying Dai  1   2 , Guo-Qing Yao  1 , Xi-Chuan Deng  3 , Guang-Chao Zang  1 , Jia Liu  3 , Guang-Yuan Zhang  1   3 , Yu-Meng Chen  1   2 , Ming-Qi Lv  1 , Ting-Ting Chen  1   3
Affiliations
Review

Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection

Wen-Ying Dai et al. J Virus Erad. .

Abstract

Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment.

Keywords: Antiviral; HSPs; Hepatitis B virus; Molecular chaperones; Vaccine adjuvant.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
HSPs are involved in acquired immunity, monokines and maturation of dendritic cells (DCs), and provide peptides for MHC-loading and antigen-specific responses.
Fig. 2
Fig. 2
Hsp90 interacts with reactive oxygen species (ROS) to promote hepatitis B (HBV) viral capsid assembly, suppresses replication upon glutathione (GSH), and promotes replication after GSH inhibition.
Fig. 3
Fig. 3
Overexpression of Hsp70 promotes both hepatitis B (HBV) replication and suppression.
Fig. 4
Fig. 4
Hsp60 impacts on hepatitis B (HBV) replication and hepatocyte apoptosis by its interaction with HBV pol and HBV virus X protein (HBx).
Fig. 5
Fig. 5
Role of the heat shock protein (HSP) family in hepatitis B (HBV) infection and immune clearance mechanisms.
See this image and copyright information in PMC

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