Creating a common language for the subanatomy of the ovary

doi:10.1093/biolre/ioac199

. 2023 Jan 14;108(1):1-4.

doi: 10.1093/biolre/ioac199.

Creating a common language for the subanatomy of the ovary

Elizabeth L Tsui^{1

2}, Kathleen E O'Neill³, Richard D LeDuc⁴, Ariella Shikanov⁵, Veronica Gomez-Lobo⁶, Monica M Laronda^{1

2}

Affiliations

¹ Department of Endocrinology and Department of Pediatric Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
² Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.
⁵ Department of Biomedical Engineering, Department of Obstetrics and Gynecology, Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, USA.
⁶ Pediatric and Adolescent Gynecology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

PMID: 36308436
PMCID: PMC9843671
DOI: 10.1093/biolre/ioac199

Creating a common language for the subanatomy of the ovary

Elizabeth L Tsui et al. Biol Reprod. 2023.

. 2023 Jan 14;108(1):1-4.

doi: 10.1093/biolre/ioac199.

Authors

Elizabeth L Tsui^{1

2}, Kathleen E O'Neill³, Richard D LeDuc⁴, Ariella Shikanov⁵, Veronica Gomez-Lobo⁶, Monica M Laronda^{1

2}

Affiliations

¹ Department of Endocrinology and Department of Pediatric Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
² Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.
⁵ Department of Biomedical Engineering, Department of Obstetrics and Gynecology, Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, USA.
⁶ Pediatric and Adolescent Gynecology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

PMID: 36308436
PMCID: PMC9843671
DOI: 10.1093/biolre/ioac199

No abstract available

Keywords: human reproduction; nomenclature; ovary; pubertal development; subanatomy.

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Figures

**Figure 1**
(A) Hematoxylin and eosin (H&E) stained section of a human ovarian biopsy from a 7.09-year-old participant. (i–iv) Inserts of A include (i) the tunica albuginea (dark green arrows), primordial and transitional follicles (green arrowheads), (ii) primary (blue arrow) and secondary follicles (oocyte nuclear material not visible, black arrow), (iii) the region between the medulla and hilum structures, and (iv) the ovarian hilum. Scale bars, 200 μm, 100 μm (i–iv). (B) H&E stained section through long plane of ovary from 16-year-old that includes the ovarian hilum structure across the bottom. Insets of B include (i) immunofluorescence images of CD31-expressing endothelial cells (red) and nuclei (DAPI, blue), which make up small capillaries (blue arrow) in the cortex, (ii) a spiral artery in the medulla (white arrow), and (iii) large vessel (white arrow) in the hilum. Scale bars, 1 mm, 100 μm (i–iii). (C) Examples of anatomical structures and cell types from the ovary ontology workflow. For example, the hilar cell *is a* cell type within the ovarian hilum, which is *part of* the ovary (UBERON identifier 0000992). The blue text represents a new anatomical structure term, and the italicized text is a proposed synonym or additional term for an existing term in UBERON ontology. Modeled after https://doi.org/10.1038/s41556-021-00788-6. An interactive version that will be updated as data is gathered is located on the HuBMAP ASCT+B Reporter platform https://hubmapconsortium.github.io/ccf-asct-reporter/ (D) Examples of updated definitions for subanatomy anatomical structure terms.

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McDowell HB, Henning NF, Laronda MM. McDowell HB, et al. Reproduction. 2024 Aug 22;168(3):e240135. doi: 10.1530/REP-24-0135. Print 2024 Sep 1. Reproduction. 2024. PMID: 38888996 Free PMC article.

References

1. Mills S. Histology for Pathologists. Lippincott Williams and Wilkins, Philadelphia; 2020.
1. Forabosco A, Sforza C. Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary. Fertil Steril 2007; 88:675–683. - PubMed
1. Reeves G. Specific stroma of the ovary. Obstet Gynecol 1971; 38:823–830. - PubMed
1. Reeves G. Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation. Obstet Gynecol Surv 1971; 27:179–181. - PubMed
1. Börner K, Teichmann SA, Quardokus EM, Gee JC, Browne K, Osumi-Sutherland D, Herr BW, Bueckle A, Paul H, Haniffa M, Jardine L, Bernard A et al. Anatomical structures, cell types and biomarkers of the human reference atlas. Nat Cell Biol 2021; 23:1117–1128. - PMC - PubMed

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[1] Mills S. Histology for Pathologists. Lippincott Williams and Wilkins, Philadelphia; 2020.

[2] Mills S. Histology for Pathologists. Lippincott Williams and Wilkins, Philadelphia; 2020.

[3] Forabosco A, Sforza C. Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary. Fertil Steril 2007; 88:675–683. - PubMed

[4] Forabosco A, Sforza C. Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary. Fertil Steril 2007; 88:675–683. - PubMed

[5] Reeves G. Specific stroma of the ovary. Obstet Gynecol 1971; 38:823–830. - PubMed

[6] Reeves G. Specific stroma of the ovary. Obstet Gynecol 1971; 38:823–830. - PubMed

[7] Reeves G. Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation. Obstet Gynecol Surv 1971; 27:179–181. - PubMed

[8] Reeves G. Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation. Obstet Gynecol Surv 1971; 27:179–181. - PubMed

[9] Börner K, Teichmann SA, Quardokus EM, Gee JC, Browne K, Osumi-Sutherland D, Herr BW, Bueckle A, Paul H, Haniffa M, Jardine L, Bernard A et al. Anatomical structures, cell types and biomarkers of the human reference atlas. Nat Cell Biol 2021; 23:1117–1128. - PMC - PubMed

[10] Börner K, Teichmann SA, Quardokus EM, Gee JC, Browne K, Osumi-Sutherland D, Herr BW, Bueckle A, Paul H, Haniffa M, Jardine L, Bernard A et al. Anatomical structures, cell types and biomarkers of the human reference atlas. Nat Cell Biol 2021; 23:1117–1128. - PMC - PubMed

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Creating a common language for the subanatomy of the ovary

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Creating a common language for the subanatomy of the ovary

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