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. 2018 Apr:222-223:1-8.
doi: 10.1016/j.cancergen.2018.01.001. Epub 2018 Feb 19.

Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata

Mark A Hayden  1 , Zehra Ordulu  2 , C Scott Gallagher  3 , Bradley J Quade  4 , Raymond M Anchan  2 , Nia Robinson Middleton  2 , Serene S Srouji  2 , Elizabeth A Stewart  5 , Cynthia C Morton  6
Affiliations

Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata

Mark A Hayden et al. Cancer Genet. 2018 Apr.

Abstract

Black women are disproportionately affected by uterine leiomyomata (UL), or fibroids, compared to other racial groups, having a greater lifetime risk of developing UL and an earlier age of diagnosis. In order to elucidate molecular and genetic mechanisms responsible for the increased prevalence and morbidity associated with UL in black women, clinical, pathologic, cytogenetic, and select molecular profiling (MED12 mutation analysis) of 75 self-reported black women undergoing surgical treatment for UL was performed. Our observations are broadly representative of previous cytogenetic studies of UL: karyotypically abnormal tumors were detected in 30.7% of women and 17.4% of analyzed tumors. No notable association was observed between race and increased occurrence of cytogenetic abnormalities that might contribute to any population-specific morbidity or prevalence rate. Our data on MED12 mutation analyses (73.2% of tumors harbored a MED12 mutation) provide additional support for a significant role of MED12 in tumorigenesis. Although the effect of MED12-mediated tumorigenesis appears significant irrespective of race, other genetic events such as the distribution of karyotypic abnormalities appear differently in black women. This case series indicates that presently recognized genetic and molecular characteristics of UL do not appear to explain the increased prevalence and morbidity of UL in black women.

Keywords: Fibroids; clinical; cytogenetic; molecular; race.

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Conflict of interest statement

The authors report no conflict of interest.

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References

    1. Bulun SE. Uterine fibroids. N Engl J Med. 2013;369:1344–55. - PubMed
    1. Buttram VC, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36:433–45. - PubMed
    1. Stewart EA. Clinical practice. Uterine fibroids New Engl J Med. 2015;372:1646–55. - PubMed
    1. Lepine LA, Hillis SD, Marchbanks PA, Koonin LM, Morrow B, Kieke BA, et al. Hysterectomy surveillance--United States, 1980–1993. Mor Mortal Wkly Rep CDC Surveill Summ. 1997;46:1–15. - PubMed
    1. Cardozo ER, Clark AD, Banks NK, Henne MB, Stegmann BJ, Segars JH. The estimated annual cost of uterine leiomyomata in the United States. Am J Obstet Gynecol. 2012;206:211e1, 9. - PMC - PubMed

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