Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment
- PMID: 28474964
- DOI: 10.1177/0003489417702655
Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment
Abstract
Background: Few studies have examined whether the use of adjuvant treatment impacts survival for early stage high-grade salivary tumors.
Methods: A retrospective review of the SEER database between 1973 and 2012 was performed. Patients with high-grade major salivary gland tumors including salivary duct carcinoma, carcinoma ex-pleomorphic adenoma, high-grade mucoepidermoid carcinoma, or adenocarcinoma, NOS were identified. Only stage I-II tumors were included. The impact of radiation status on observed and relative survival was examined.
Results: Five hundred seventy-four patients with high-grade, early stage salivary tumors met inclusion criteria. Sixty-seven percent of patients received radiation therapy. There was no difference in observed or relative survival based on having received radiation.
Conclusions: Adjuvant radiation is indicated for advanced stage tumors or early stage tumors with adverse features. For early stage tumors without adverse features, there was no survival benefit from radiation therapy. Adjuvant radiation should be decided on a case-by-case basis for these patients.
Keywords: cancer; malignancy; radiation; salivary gland cancer; treatment of head and neck tumors.
Similar articles
-
Carcinoma ex pleomorphic adenoma: a clinicopathologic review.Head Neck. 2001 Sep;23(9):705-12. doi: 10.1002/hed.1100. Head Neck. 2001. PMID: 11505478
-
Management of nasopharyngeal salivary gland malignancy.Laryngoscope. 2001 Sep;111(9):1533-44. doi: 10.1097/00005537-200109000-00009. Laryngoscope. 2001. PMID: 11568602
-
Management of minor salivary gland carcinomas.Int J Radiat Oncol Biol Phys. 1996 Jun 1;35(3):443-54. doi: 10.1016/s0360-3016(96)80005-8. Int J Radiat Oncol Biol Phys. 1996. PMID: 8655366
-
[Tumors of the minor salivary glands located in the hard palate].Tumori. 2003 Jul-Aug;89(4 Suppl):231-2. Tumori. 2003. PMID: 12903602 Review. Italian. No abstract available.
-
Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature.Oral Dis. 2006 Jul;12(4):364-70. doi: 10.1111/j.1601-0825.2005.01166.x. Oral Dis. 2006. PMID: 16792720 Review.
Cited by
-
Management of Non-High-Risk Salivary Gland Carcinomas With Surgery Alone.Cureus. 2021 Aug 7;13(8):e16970. doi: 10.7759/cureus.16970. eCollection 2021 Aug. Cureus. 2021. PMID: 34540381 Free PMC article.
-
Kaplan-Meier analysis of salivary gland tumors: prognosis and long-term survival.J Cancer Res Clin Oncol. 2019 Aug;145(8):2123-2130. doi: 10.1007/s00432-019-02953-9. Epub 2019 Jun 11. J Cancer Res Clin Oncol. 2019. PMID: 31187201
-
Postoperative Chemoradiotherapy versus Radiotherapy Alone in Major Salivary Gland Cancers: A Stratified Study Based on the External Validation of the Distant Metastasis Risk Score Model.Cancers (Basel). 2022 Nov 14;14(22):5583. doi: 10.3390/cancers14225583. Cancers (Basel). 2022. PMID: 36428676 Free PMC article.
-
Mammary analogue secretory carcinoma of salivary glands: diagnostic pitfall with distinct immunohistochemical profile and molecular features.Rare Tumors. 2017 Oct 3;9(3):7162. doi: 10.4081/rt.2017.7162. eCollection 2017 Oct 3. Rare Tumors. 2017. PMID: 29081930 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
