Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B
- PMID: 2654643
- DOI: 10.1038/339070a0
Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B
Abstract
The latent period of AIDS is influenced by factors which activate human immunodeficiency virus (HIV) replication in different cell types. Although monocytic cells may provide a reservoir for virus production in vivo, their regulation of HIV transcription has not been defined. We now report that HIV gene expression in the monocyte lineage is regulated by NF-kappa B, the same transcription factor known to stimulate the HIV enhancer in activated T cells; however, control of NF-kappa B and HIV in monocytes differs from that observed in T cells. NF-kappa B-binding activity appears during the transition from promonocyte to monocyte in U937 cells induced to differentiate in vitro and is present constitutively in mature monocytes and macrophages. In a chronically infected promonocytic cell, U1, differentiation is associated with HIV-1 replication as well as NF-kappa B binding activity. These findings suggest that NF-kappa B binding activity is developmentally regulated in the monocyte lineage, and that it provides one signal for HIV activation in these cells.
Comment in
-
NF-kB and HIV.Nature. 1990 Jan 18;343(6255):218-9. doi: 10.1038/343218b0. Nature. 1990. PMID: 2405277 No abstract available.
Similar articles
-
IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.J Immunol. 1996 Jan 15;156(2):841-51. J Immunol. 1996. PMID: 8543841
-
Regulation of the IL-2 receptor alpha-gene. Interaction of a kappa B binding protein with cell-specific transcription factors.J Immunol. 1989 Nov 1;143(9):3064-8. J Immunol. 1989. PMID: 2809216
-
HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes.Nature. 1991 Apr 25;350(6320):709-12. doi: 10.1038/350709a0. Nature. 1991. PMID: 2023633
-
NF-kappa B and HIV: linking viral and immune activation.Adv Pharmacol. 2000;48:161-207. doi: 10.1016/s1054-3589(00)48006-3. Adv Pharmacol. 2000. PMID: 10987091 Review. No abstract available.
-
Regulation of hepatocyte gene expression: progress on the horizon.Hepatology. 1989 Dec;10(6):1017-8. doi: 10.1002/hep.1840100622. Hepatology. 1989. PMID: 2684836 Review. No abstract available.
Cited by
-
Genetic variation and HIV-associated neurologic disease.Adv Virus Res. 2013;87:183-240. doi: 10.1016/B978-0-12-407698-3.00006-5. Adv Virus Res. 2013. PMID: 23809924 Free PMC article. Review.
-
The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.Cell Host Microbe. 2012 Feb 16;11(2):181-93. doi: 10.1016/j.chom.2011.12.005. Cell Host Microbe. 2012. PMID: 22341466 Free PMC article.
-
Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level.Biochem J. 2003 Jan 15;369(Pt 2):331-9. doi: 10.1042/BJ20020253. Biochem J. 2003. PMID: 12350227 Free PMC article.
-
Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1839-42. doi: 10.1073/pnas.90.5.1839. Proc Natl Acad Sci U S A. 1993. PMID: 8446597 Free PMC article.
-
Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro.Arch Virol. 1993;130(3-4):463-9. doi: 10.1007/BF01309674. Arch Virol. 1993. PMID: 8517797
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
