Effects of poly(ethylene glycol) grafting density on the tumor targeting efficacy of nanoparticles with ligand modification
- PMID: 24215373
- DOI: 10.3109/10717544.2013.854849
Effects of poly(ethylene glycol) grafting density on the tumor targeting efficacy of nanoparticles with ligand modification
Abstract
To evaluate the effects of poly(ethylene glycol) (PEG) grafting density on the tumor targeting efficacy of nanoparticles (NPs) with ligand modification, various amounts of PEG were conjugated to linoleic acid and poly(β-malic acid) double grafted chitosan (LMC) NPs bearing similar substitution degree of folate (FA). Increased particle size, decreased surface charge, reduced contact angle, retarded drug release and suppressed protein adsorption of LMC NPs were detected after surface modification. Compared to LMC NPs, FA-modified LMC NPs (FA-LMC NPs) remarkably enhanced tumor specificity. For PEG-modified FA-LMC NPs, increased drug accumulation in tumor tissues and reduced cellular uptake were observed with the increase of PEG grafting density. In regard to in vivo antitumor efficacy, FA-LMC NPs with moderate PEG grafting density (8.9%) significantly outperformed FA-LMC NP. Therefore, PEG modification with moderate grafting density could be a promising approach to coordinating with the tumor targeting efficacy of ligand-modified NPs.
Keywords: Grafting density; hydrophilic polymers; nanoparticles; surface modification; targeted delivery.
Similar articles
-
Enhanced antitumor efficacy of folate modified amphiphilic nanoparticles through co-delivery of chemotherapeutic drugs and genes.Biomaterials. 2014 Aug;35(24):6369-78. doi: 10.1016/j.biomaterials.2014.04.095. Epub 2014 May 10. Biomaterials. 2014. PMID: 24818887
-
Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs.Biomacromolecules. 2009 Mar 9;10(3):565-72. doi: 10.1021/bm801225m. Biomacromolecules. 2009. PMID: 19175304
-
Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: for the potential targeted ovarian cancer gene therapy.Eur J Pharm Sci. 2014 Feb 14;52:48-61. doi: 10.1016/j.ejps.2013.10.011. Epub 2013 Oct 29. Eur J Pharm Sci. 2014. PMID: 24178005
-
Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review.Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):427-43. doi: 10.1016/j.ejpb.2013.07.002. Epub 2013 Jul 17. Eur J Pharm Biopharm. 2013. PMID: 23872180 Review.
-
Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery.Pharm Res. 2007 Aug;24(8):1405-14. doi: 10.1007/s11095-007-9284-6. Epub 2007 Mar 29. Pharm Res. 2007. PMID: 17393074 Review.
Cited by
-
Transferrin-Bearing, Zein-Based Hybrid Lipid Nanoparticles for Drug and Gene Delivery to Prostate Cancer Cells.Pharmaceutics. 2023 Nov 20;15(11):2643. doi: 10.3390/pharmaceutics15112643. Pharmaceutics. 2023. PMID: 38004621 Free PMC article.
-
Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery.Drug Deliv. 2022 Dec;29(1):1060-1074. doi: 10.1080/10717544.2022.2058645. Drug Deliv. 2022. PMID: 35363113 Free PMC article.
-
Influence of surface chemistry and morphology of nanoparticles on protein corona formation.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Jul;14(4):e1788. doi: 10.1002/wnan.1788. Epub 2022 Mar 7. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022. PMID: 35257495 Free PMC article. Review.
-
Regression of Melanoma Following Intravenous Injection of Plumbagin Entrapped in Transferrin-Conjugated, Lipid-Polymer Hybrid Nanoparticles.Int J Nanomedicine. 2021 Apr 6;16:2615-2631. doi: 10.2147/IJN.S293480. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33854311 Free PMC article.
-
Development of tamoxifen-loaded surface-modified nanostructured lipid carrier using experimental design: in vitro and ex vivo characterisation.IET Nanobiotechnol. 2020 Jun;14(4):261-274. doi: 10.1049/iet-nbt.2019.0276. IET Nanobiotechnol. 2020. PMID: 32463016 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
