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Randomized Controlled Trial
. 2012 Jun 18:11:44.
doi: 10.1186/1475-2891-11-44.

The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women

Alma Rosa Tovar  1 , María del Carmen Caamaño, Sandra Garcia-Padilla, Olga Patricia García, Miguel Angel Duarte, Jorge L Rosado
Affiliations
Randomized Controlled Trial

The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women

Alma Rosa Tovar et al. Nutr J. .

Abstract

Background: Obesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women.

Methods: In a randomized controlled clinical trial 144 women (18-50 y) with BMI ≥ 25 kg/m², were allocated into one of the following treatments during 3 months: 1) Two doses/d of a partial meal replacement (PMR), 2) Two doses/d of PMR with inulin (PMR + I) , 3) Two doses/d of 5 g of inulin (INU) and 4) Control group (CON). All groups received a low calorie diet (LCD). Weight, height, hip and waist circumference were measured every 2 weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3 months.

Results: All groups significantly reduced weight, BMI, waist and hip circumference. Differences between groups were only observed in BMI and weight adjusted changes: At 45 days PMR group lost more weight than INU and CON groups by 0.9 and 1.2Kg, respectively. At 60 days, PMR + I and PMR groups lost more weight than in INU by 0.7 and 1Kg, respectively. Subjects in PMR, PMR + I and INU significantly decreased triglycerides. Energy intake was reduced in all groups. Fiber intake increased in PMR + I and INU groups. Some minerals and vitamins intakes were higher in PMR and PMR + I compared with INU and CON groups.

Conclusion: Inclusion of PMR with and without inulin to a LCD had no additional effect on weight reduction than a LCD alone but reduced triglycerides and improved intake of micronutrients during caloric restriction. PMR could be a good alternative for obese populations with micronutrient deficiencies.

Trial registration: ClinicalTrials.gov NCT01505023.

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Figures

Figure 1
Figure 1
Flow-chart.
Figure 2
Figure 2
Body weight change by treatment group. Values are estimated mean changes adjusted for the initial value. a, b Different letters mean significant difference between treatments. PMR + I = Partial meal replacement with inulin, PMR = Partial meal replacement, INU = Inulin, CON = control.
Figure 3
Figure 3
Waist circumference change by treatment group. Values are estimated mean changes adjusted for the initial value. Different letters mean significant difference between treatments. PMR = Partial meal replacement with inulin, PMR = Partial meal replacement, INU = Inulin, CON = control group.
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