Advances in the understanding of mammalian copper transporters
- PMID: 22332042
- PMCID: PMC3065767
- DOI: 10.3945/an.110.000273
Advances in the understanding of mammalian copper transporters
Abstract
Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu(1+) and Cu(2+)) allows it to function as an enzymatic cofactor in hydrolytic, electron transfer, and oxygen utilization reactions. Cu transporters CTR1, ATP7A, and ATP7B play key roles in ensuring that adequate Cu is available for Cu-requiring processes and the prevention of excess Cu accumulation within cells. Two diseases of Cu metabolism, Menkes disease and Wilson disease, which are caused by mutations in ATP7A and ATP7B, respectively, exemplify the critical importance of regulating Cu balance in humans. Herein, we review recent studies of the biochemical and cell biological characteristics of CTR1, ATP7A, and ATP7B, as well as emerging roles for Cu in new areas of physiology.
Conflict of interest statement
Author disclosures: Y. Wang, V. Hodgkinson, S. Zhu, G. A. Weisman, and M. J. Petris, no conflicts of interest.
Figures
![Figure 1](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c110/3065767/e6a8ba96690f/129fig1.gif)
![Figure 2](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c110/3065767/83a601f24429/129fig2.gif)
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References
-
- Andreini C, Banci L, Bertini I, Rosato A. Occurrence of copper proteins through the three domains of life: a bioinformatic approach. J Proteome Res. 2008;7:209–16 - PubMed
-
- Puig S, Lee J, Lau M, Thiele DJ. Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J Biol Chem. 2002;277:26021–30 - PubMed
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