SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
- PMID: 21081649
- DOI: 10.1242/jcs.073783
SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
Erratum in
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Correction: SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310 (doi:10.1242/jcs.073783).J Cell Sci. 2019 Apr 24;132(8):jcs232801. doi: 10.1242/jcs.232801. J Cell Sci. 2019. PMID: 31018986 No abstract available.
Abstract
NF-κB regulates the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis, cell proliferation, differentiation and survival. In this study, we identified SIRT2 as a deacetylase of the transcription factor p65. SIRT2 is a member of the family of sirtuins, which are NAD(+)-dependent deacetylases involved in several cellular processes. SIRT2 interacts with p65 in the cytoplasm and deacetylates p65 in vitro and in vivo at Lys310. Moreover, p65 is hyperacetylated at Lys310 in Sirt2(-/-) cells after TNFα stimulation, which results in the increase in expression of a subset of p65 acetylation-dependent target genes. Our work provides evidence that p65 is deacetylated by SIRT2 in the cytoplasm to regulate the expression of specific NF-κB-dependent genes.
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