Review
doi: 10.1038/35036052.
Lipid rafts and signal transduction
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- PMID: 11413487
- DOI: 10.1038/35036052
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Review
Lipid rafts and signal transduction
Nat Rev Mol Cell Biol.
2000 Oct.
Erratum in
- Nat Rev Mol Cell Biol 2001 Mar;2(3):216
Abstract
Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.
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