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Published online 2018 May 2. doi: 10.1152/physrev.00023.2017
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Table 1.

Pathological conditions that are alleviated by NRF2 activation or exacerbated by NRF2 disruption

Modifying Strategy of NRF2 Activity
DiseaseSpeciesPharmacologicalGeneticReference Nos.
Chronic kidney diseaseHumanBardoxolone methyl (CDDO-Me)33, 171
Acute kidney diseaseMouseBardoxolone methyl (CDDO-Me) 251
Diabetic nephropathyMouseNrf2–/– mice 83
Hyperoxic acute lung injuryMouseCDDO-ImNrf2–/– mice26, 181
PleurisyMouse15D-PGJ2Nrf2–/– mice 81
EmphysemaMouseCDDO-ImNrf2–/– mice 216
Allergic asthmaMouseKeap1F/F:CAG-CreERT2 mice + tamoxifen 217
Lung carcinogenesisMouseCDDO-Im, CDDO-Me 231
Pulmonary hypertensionMouseOltiprazNrf2–/– mice, Keap1F/F (knockdown; KD) mice 46
Cardiac ischemia-reperfusionMouse15D-PGJ2Nrf2–/– mice 95
Cardiac hypertrophyMouseDihydro-CDDO-TEA 252
Multiple sclerosisMouseFumaric acid estersNrf2–/– mice 127
Multiple sclerosisHumanBG2 (dimethyl fumarate)54, 59
Alzheimer’s diseaseMouseLentiviral expression of NRF2 91
Parkinson’s diseaseMouseTriterpenoids 86
Huntington’s diseaseMouseTriterpenoids 214
Amyotrophic lateral sclerosisMouseTriterpenoids 155
Cerebral ischemia-reperfusionMouseNeurite outgrowth-promoting prostaglandin (NEPPs) 196
Type 2 diabetesMouseCDDO-ImNrf2–/– mice, Keap1F/– (KD) mice 237
Type 1 diabetesMouseSulforaphane 212
ObesityMouseCDDO-ImNrf2–/– mice 203
Acetaminophen hepatotoxicityMouseCDDO-ImNrf2–/– mice50, 183
Gastric carcinogenesisMouseOltipraz, sulforaphaneNrf2–/– mice51, 178
Aflatoxin-induced liver carcinogenesisRatCDDO-ImNrf2–/– mice84, 225, 263
Helicobacter pylori colonizationMouseSulforaphaneNrf2–/– mice 262
UV-induced dermatitisMouseTBE-31Nrf2–/– mice, Keap1F/F (KD) mice 106
X-ray irradiation-induced dermatitisMouseSynthetic triterpenoid RTA 408 184
Diabetic retinopathyMouseNrf2–/– mice 253
Fuchs endothelial corneal dystrophy (FECD)Human tissue cultureSulforaphane 269
Noise-induced hearing lossHuman, mouseCDDO-ImNrf2–/– mice 64
Rheumatoid arthritisMouseNrf2–/– mice 130
SepsisMouseCDDO-ImNrf2–/– mice 230
Renal ischemia-reperfusionMouseCDDO-ImNrf2–/– mice, Keap1F/F (KD) mice 156