. 2010 Jan 29;115(1):214–224. doi: 10.1093/toxsci/kfq030

TABLE 1.

Effect of PFOA Treatment on the Expression Levels of Liver Drug Metabolic Enzymes Related to Steroid Hormone Metabolism/Excretion in Wild-Type and PPARα Knock Mice

Description of liver drug metabolic enzymes	PFOA-treated wild-type mice (fold of change)^a	PFOA-treated PPARα knockout mice (fold of change)
Cytochrome P450, family 1, subfamily a, polypeptide 1	−2.5 ± 0.45^*	No change
Cytochrome P450, family 1, subfamily a, polypeptide 2	−3.4 ± 1.14^*	No change
Catechol-o-methyltransferase	−2.1 ± 0.32^*	No change
HSD17β2	−3.4 ± 0.62^*	No change
HSD17β4	3.9 ± 1.05^*	No change
SULT1A1	−7.1 ± 2.14^*	No change
SULT1E1	−14.4 ± 1.24^*	No change
Ugt2A1	−2.3 ± 0.78^*	No change
Ugt2B1	−2.0 ± 0.31	No change

Note. Three-week-old wild-type and PPARα knockout C57Bl/6 mice were treated with vehicle control or PFOA (5 mg/kg) for 4 weeks and sacrificed 24 h after the last treatment. Total RNA was extracted from frozen liver samples and used for the synthesis of first-strand cDNAs that were used for liver drug metabolic enzyme qPCR array analysis as described in the “Materials and Methods” section.

Fold change is expressed as mean ± SD (n = 3).

p < 0.05, compared with respective vehicle control–treated mice.