Differential Effects of Peripubertal Exposure to Perfluorooctanoic Acid on Mammary Gland Development in C57Bl/6 and Balb/c Mouse Strains

Chengfeng Yang; Ying S. Tan; Jack R. Harkema; Sandra Z. Haslam

doi:10.1016/j.reprotox.2008.10.003

Fig. 4

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Effect of PFOA treatment on the timing of vaginal opening

Mice were treated with vehicle control or indicated doses of PFOA as described in Materials and Methods. Appearance of vaginal opening was monitored and recorded daily. Time-course of the timing of vaginal opening in vehicle- or PFOA-treated (A) Balb/ c or (B) C57BL/6 mice. Data are presented as the percent (%) of mice with vaginal opening at indicated day of age.