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Astrocytes are enablers of brain metastases
Circulating tumour cells from primary carcinomas may reach the brain and establish metastases. In the brain parenchyma, tumour cells initiate extensive interactions with resident astrocytes, microglia and neurons, forming a niche where tumour cells can thrive. A new study reveals a previously unknown type of astrocyte–tumour cell interaction.
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Focus on cell death
Our understanding of distinct and diverse modes of cell death and their contributions to homeostasis and disease has significantly progressed in recent years. In this Focus, we highlight exciting advances in this field with commissioned content, an Editorial, Research Highlights and a selection of related research articles published by Nature Cell Biology.