Modifying an E2 ubiquitin-conjugating enzyme with a binding domain creates an encodable strategy for driving targeted protein degradation within eukaryotic cells.

The authors performed a GWAS for pelvic organ prolapse (POP) in Japanese women, and identified WT1 as a susceptibility locus for POP in Japanese women. Transethnic GWAS meta-analysis further identified FGFR2 as an additional susceptibility locus for POP.

Phylogenomic analysis and TIRF microscopy were used to investigate the role of actin and myosin in diatom gliding. The findings support the involvement of three raphid diatom-specific myosins in force generation during cell movement.

Exploring virtual pharmacological treatments using whole-brain models and deep learning reveals improvements in disorders of consciousness models when stimulating serotonergic and opioid receptors.

Serially mechanistic studies reveal the role of ferroptosis in disrupting the normal excitatory-inhibitory balance of the motor cortex after overexpressing human α-synuclein.

The authors performed a GWAS for pelvic organ prolapse (POP) in Japanese women, and identified WT1 as a susceptibility locus for POP in Japanese women. Transethnic GWAS meta-analysis further identified FGFR2 as an additional susceptibility locus for POP.

Graph theoretical properties of resting-state networks are more heritable for source-level MEG compared to fMRI, and brain network features can serve as genetic fingerprints to accurately identify identical twins in a cohort.

The tracking of continuous speech is examined with high-field fMRI. In two-speaker scenes, speech tracking of the BOLD signal suggests distinct roles of Heschl’s gyrus and superior temporal sulcus for processing relevant and non-relevant speech.

This methodological study examines the effects of temperature and formaldehyde concentration on the analysis of genome organization by chromosome conformation capture approaches and reveals that changes in these two key parameters can greatly affect the outcome and reproducibility of the analysis.

Low protein diet protects against Salmonella Typhimurium-mediated liver injury in mice corresponding to reduced mTOR activation and increased autophagy in macrophages. mTOR pathway activation with amino acid supplementation reverses this protection.

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.