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Cardiac multiomics

Spatially resolved multiomics reveals the microanatomy of the human heart

Nature Cardiovascular Research volume 2, pages 798–800 (2023)Cite this article

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Spatially resolved multiomics is an emerging approach for profiling gene expression at the cellular level while maintaining the spatial organization of tissues. Its application in healthy human hearts provides insight into ion channels and regulatory signaling in the cardiac conduction system, cardiac cellular niches and drug–cell interactions.

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Fig. 1: Cardiac niche characterization from spatially resolved multiomics and future applications for drug2cell.

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Acknowledgements

S.J. is supported by the Sarnoff Foundation. S.L.R. has a Career Award from the Burroughs Wellcome Foundation.

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Authors and Affiliations

  1. Department of Medicine, Cardiovascular Division, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    Samuel Jordan & Stacey L. Rentschler

  2. Department of Developmental Biology, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    Stacey L. Rentschler

  3. Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA

    Stacey L. Rentschler

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  1. Samuel Jordan
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  2. Stacey L. Rentschler
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Correspondence to Stacey L. Rentschler.

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The authors declare no competing interests.

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Jordan, S., Rentschler, S.L. Spatially resolved multiomics reveals the microanatomy of the human heart. Nat Cardiovasc Res 2, 798–800 (2023). https://doi.org/10.1038/s44161-023-00327-6

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