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3D GENOMICS

Jumping retroviruses nudge TADs apart

Nature Genetics volume 51, pages 1304–1305 (2019)Cite this article

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Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study demonstrates how the transcription of one such element, HERV-H, can modify the higher-order 3D structure of chromatin during early primate development.

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Fig. 1: Functionally co-opted ERVs have diverse activities.

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Authors and Affiliations

  1. RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany

    Michael I. Robson & Stefan Mundlos

  2. Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany

    Stefan Mundlos

  3. Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin Berlin, Berlin, Germany

    Stefan Mundlos

Authors
  1. Michael I. Robson
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  2. Stefan Mundlos
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Correspondence to Stefan Mundlos.

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The authors declare no competing interests.

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Robson, M.I., Mundlos, S. Jumping retroviruses nudge TADs apart. Nat Genet 51, 1304–1305 (2019). https://doi.org/10.1038/s41588-019-0491-y

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