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Stem cells

Fgfbp1+ cells: upper crypt intestinal epithelial regeneration

Nature Reviews Gastroenterology & Hepatology volume 21, page 534 (2024)Cite this article

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A new study published in Cell has identified a novel regenerative stem cell population in the upper crypt of the intestinal epithelium. The cells, which express Fgfbp1 and are distinct from Lgr5+ cells, were shown using time-resolved fate mapping and lineage tracing to give rise to Lgr5+ crypt base columnar cells and all other intestinal lineages — and continued to regenerate the intestinal epithelium after depletion of Lgr5+ cells. In addition, Fgfbp1 conditional knockout experiments in mice showed that FGFBP1 expression by upper crypt stem cells is essential for crypt regeneration and intestinal epithelial homeostasis.

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References

Original article

  • Capdevila, C. et al. Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Cell 187, 3039–3055.E14 (2024)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Jordan Hindson

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  1. Jordan Hindson
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Correspondence to Jordan Hindson.

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Hindson, J. Fgfbp1+ cells: upper crypt intestinal epithelial regeneration. Nat Rev Gastroenterol Hepatol 21, 534 (2024). https://doi.org/10.1038/s41575-024-00965-6

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  • DOI: https://doi.org/10.1038/s41575-024-00965-6

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