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Cancer

A lower bar for senescence

Nature volume 464, pages 363–364 (2010)Cite this article

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Cellular senescence is a physiological mechanism for thwarting the proliferation of tumour cells. Encouraging cancer-prone cells to senesce might therefore be a way to nip this disease in the bud.

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Figure 1: Manipulating the threshold for senescence.

References

  1. Vijg, J. & Dolle, M. E. Mech. Ageing Dev. 123, 907–915 (2002).

    Article  CAS  Google Scholar 

  2. Lin, H.-K. et al. Nature 464, 374–379 (2010).

    Article  ADS  CAS  Google Scholar 

  3. Campaner, S. et al. Nature Cell Biol. 12, 54–59 (2010).

    Article  CAS  Google Scholar 

  4. Collado, M., Blasco, M. A. & Serrano, M. Cell 130, 223–233 (2007).

    Article  CAS  Google Scholar 

  5. Xue, W. et al. Nature 445, 656–660 (2007).

    Article  CAS  Google Scholar 

  6. Collado, M. & Serrano, M. Nature Rev. Cancer 10, 51–57 (2010).

    Article  CAS  Google Scholar 

  7. Malumbres, M. & Barbacid, M. Nature Rev. Cancer 9, 153–166 (2009).

    Article  CAS  Google Scholar 

  8. Nakayama, K. I. & Nakayama, K. Semin. Cell Dev. Biol. 16, 323–333 (2005).

    Article  CAS  Google Scholar 

  9. Soucy, T. A. et al. Nature 458, 732–736 (2009).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Manuel Serrano is at the Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernàndez Almagro Street, Madrid E-28029, Spain. mserrano@cnio.es,

    Manuel Serrano

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  1. Manuel Serrano
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Serrano, M. A lower bar for senescence. Nature 464, 363–364 (2010). https://doi.org/10.1038/464363a

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