If it is not repaired efficiently, damage to DNA double strands can have dire consequences for both the cell and the organism. Given the gravity of this situation, cells use two pathways to start the process.
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Klein, H. DNA endgames. Nature 455, 740–741 (2008). https://doi.org/10.1038/455740a
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DOI: https://doi.org/10.1038/455740a
