Article
|
Open Access
Featured
-
-
Article
| Open Access
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development
Neuronal development is tightly controlled by nutrients and antioxidants. Here, authors show that ferroptosis, a cell death modality driven by lipid peroxidation, is required to be suppressed by vitamin A or antioxidants to ensure proper neuronal development.
- Juliane Tschuck
- , Vidya Padmanabhan Nair
- & Kamyar Hadian
-
Article
| Open Access
Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress
Here the authors show that the patterning signals WNT, BMP, and FGF control chromosome segregation fidelity during early lineage specification and neurogenesis, which could provide a rationale for the spatio-temporal distribution of genomic mosaicism during human development.
- Anchel de Jaime-Soguero
- , Janina Hattemer
- & Sergio P. Acebrón
-
Article
| Open Access
Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning
How Draper activates phagocytosis is not well understood. Here, the authors show that two Drosophila galectins, Hdg and Ctg, are secreted from hemocytes after dendrite injury and bridge phosphatidylserine and Draper to active phagocytosis.
- Hsin-Ho Sung
- , Hsun Li
- & Cheng-Ting Chien
-
Article
| Open Access
Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc
The authors show that synergistic activation by two transcription factors - Pointed, which is activated by cell–cell signaling, and Glass, which is eye-specific - drives a program of neuronal gene expression in developing Drosophila photoreceptors.
- Hongsu Wang
- , Komal Kumar Bollepogu Raja
- & Jessica E. Treisman
-
Article
| Open Access
Motor innervation directs the correct development of the mouse sympathetic nervous system
How tissues interact to help each other grow is a major question for biologists. Here, the authors show that motor innervation controls positioning of sympathetic progenitor cells to ensure correct shaping of ganglia in the peripheral nervous system.
- Alek G. Erickson
- , Alessia Motta
- & Igor Adameyko
-
Article
| Open Access
Single cell dual-omic atlas of the human developing retina
The authors build an atlas of the human retinal development, using approximately 220,000 nuclei from 14 embryos and fetuses (8–23 weeks post-conception). The study reveals major cell classes, key transcription factors, and differences in the development of macular and peripheral retina.
- Zhen Zuo
- , Xuesen Cheng
- & Rui Chen
-
Article
| Open Access
Adult neurogenesis improves spatial information encoding in the mouse hippocampus
Adult neurogenesis is a unique form of neuronal plasticity, involving the genesis and integration of newborn neurons into the mouse dentate gyrus. Here the authors demonstrate that adult neurogenesis improves representations of space in the dentate gyrus by increasing the place-specific responses of mature neurons.
- M. Agustina Frechou
- , Sunaina S. Martin
- & J. Tiago Gonçalves
-
Article
| Open Access
Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation
Messenger RNAs (mRNAs) harboring rare codons are upregulated in the Drosophila brain. In this study, the authors demonstrate that such rare codon mRNAs are present in Drosophila neurons but not in neuroblast cells, and that Orb2 positively regulates rare-codon-dependent mRNA stability in neurons.
- Rebeccah K. Stewart
- , Patrick Nguyen
- & Donald T. Fox
-
Article
| Open Access
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
TBI patients may develop long-term cognitive issues and neurodegenerative diseases. Here, the authors show that TBI induces structural changes in the mouse hippocampus by promoting neurogenesis at the cost of astrogliogenesis, and cellular dysplasia.
- P. Bielefeld
- , A. Martirosyan
- & C. P. Fitzsimons
-
Article
| Open Access
m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis
Here, the authors identify MeCP2 as a cytosine methylated RNA reader protein that binds directly to m5C modified lncRNA lnRncr3 to maintain the neural progenitor pool and to block the processing of the embedded miR124a to limit neuronal differentiation.
- Jing Zhang
- , Huili Li
- & Lee A. Niswander
-
Article
| Open Access
Dan forms condensates in neuroblasts and regulates nuclear architecture and progenitor competence in vivo
The genome is actively organized in progenitors to regulate their capacity to produce different cell types. Here, the authors show that a nuclear architecture protein forms condensates and controls the physical location of the genomic locus of a key competence transcription factor.
- Gillie Benchorin
- , Richard Jangwon Cho
- & Minoree Kohwi
-
Article
| Open Access
Protein translation rate determines neocortical neuron fate
Here the authors demonstrate how protein translation, controlled by Ire1α, regulates neuronal diversification in the developing neocortex.
- Ekaterina Borisova
- , Andrew G. Newman
- & Mateusz C. Ambrozkiewicz
-
Article
| Open Access
Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature
The role of subcellular thermogenesis during neuronal differentiation remains poorly understood. Here, the authors employ methods to monitor local intracellular temperature, and they investigate the effects of non-invasive temperature changes on cell differentiation using neuron-like cells.
- Shunsuke Chuma
- , Kazuyuki Kiyosue
- & Yoshie Harada
-
Article
| Open Access
Noncanonical function of folate through folate receptor 1 during neural tube formation
Neural tube defects are common birth defects that have been shown to be reduced through periconceptional folate supplementation, though the mechanism for this effect is unclear. Here they show that FOLR1 is necessary for neural tube formation in human neural organoids and Xenopus laevis embryos, and that this role is independent of its folate transport function.
- Olga A. Balashova
- , Alexios A. Panoutsopoulos
- & Laura N. Borodinsky
-
Article
| Open Access
Developmental basis of SHH medulloblastoma heterogeneity
The role of developmental pathways in medulloblastoma tumours (MB) with sonic hedgehog (SHH) activation remains to be explored. Here, the authors perform multi-omic analysis and characterise the key transcriptomic and metabolic patterns of highly differentiated cells in SHH MBs.
- Maxwell P. Gold
- , Winnie Ong
- & Ernest Fraenkel
-
Article
| Open Access
Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
The molecular mechanisms controlling injury-dependent neuronal regeneration are largely unknown. Here, the authors use integrated multiomic analysis to characterize gene regulatory networks controlling injury-induced neurogenesis in zebrafish retina
- Pin Lyu
- , Maria Iribarne
- & Seth Blackshaw
-
Article
| Open Access
Mechanical control of neural plate folding by apical domain alteration
Theoretical and experimental observations argue that apical domain heterogeneity in the neural plate is a tug-of-war contest between constricted and elongated cells. This competition likely reflects mechanical forces operating during tissue bending.
- Miho Matsuda
- , Jan Rozman
- & Sergei Y. Sokol
-
Article
| Open Access
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors
Zhang et al. report that KDM2B-∆CxxC activated Wnt signaling in the developing hippocampi, where the migration and differentiation of neural progenitors were blocked. KDM2B-∆CxxC mice exhibited defects of hippocampal morphology and related behaviors.
- Bo Zhang
- , Chen Zhao
- & Yan Zhou
-
Article
| Open Access
Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke
The functions of newborn cells arising from the subventricular zone in response to stroke have been unclear. Here, the authors show that cells migrating from the subventricular zone after stroke promote brain repair and functional recovery in mice.
- Michael R. Williamson
- , Stephanie P. Le
- & Michael R. Drew
-
Article
| Open Access
Non-uniform temporal scaling of developmental processes in the mammalian cortex
Marsupial mammals take much longer to develop than similarly sized placental mammals, though how brain development occurs across these different periods is unclear. Here they show that the neurodevelopmental events of cortical neurogenesis, cell migration and axon extension do not all temporally scale to the same extent.
- Annalisa Paolino
- , Elizabeth H. Haines
- & Laura R. Fenlon
-
Article
| Open Access
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
Exercise has positive effects on the brain during aging. Here the authors show that in mice, platelet-released exerkine PF4 mediates the effects of exercise on the brain.
- Odette Leiter
- , David Brici
- & Tara L. Walker
-
Article
| Open Access
NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
Endodermal neurogenesis is an uncommon trait among animals. Here they identify a population of endoderm-specific neural progenitor cells in the cnidarian Nematostella vectensis that is characterized by the expression of the transcription factor prdm14d.
- Quentin I. B. Lemaître
- , Natascha Bartsch
- & Fabian Rentzsch
-
Article
| Open Access
SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development
The balance of stem cell maintenance, differentiation, and programmed death is critical for proper development. Here they show that SNIP1 is critical for stem cell survival and differentiation in the developing brain where it acts downstream of TGFb and NFkB and regulates PRC2 activities for governing cell fates.
- Yurika Matsui
- , Mohamed Nadhir Djekidel
- & Jamy C. Peng
-
Article
| Open Access
Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey
Proteomic data covering fetal and neonatal primate brain development in the primate brain is needed to understand development and changes in functional gene products. Here, the authors show the dynamic proteomic changes of the cynomolgus macaque brain during the development from early fetal to neonatal stages by constructing a spatiotemporal proteomic atlas.
- Jingkuan Wei
- , Shaoxing Dai
- & Wei Si
-
Article
| Open Access
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition
The usage of specific distal regulatory regions within the genome is critical for fate specification and cell maturation. Here, the authors show that the accumulation of the oncoprotein SET, as occurring in the rare Schinzel-Giedion syndrome, and associated histone hypo-acetylation interfere with normal enhancer repertoire employed during brain development.
- Mattia Zaghi
- , Federica Banfi
- & Alessandro Sessa
-
Article
| Open Access
Asymmetric activity of NetrinB controls laterality of the Drosophila brain
Brain asymmetry is widespread across species, but its function remains poorly understood. Here, the authors show that the Netrin axon guidance pathway is involved in building an asymmetric neural circuit important for long-term memory in Drosophila.
- F. Lapraz
- , C. Boutres
- & S. Noselli
-
Article
| Open Access
Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.
- Weam S. Shahin
- , Shima O. Ebed
- & John F. Engelhardt
-
Article
| Open Access
Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis
Here the authors identify RNA-binding protein MEX3A as a post-transcriptional regulator of quiescence and differentiation signatures at critical transitions along the murine subependymal neurogenic lineage
- Ana Domingo-Muelas
- , Pere Duart-Abadia
- & Isabel Fariñas
-
Article
| Open Access
CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder
Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder with unclear underlying mechanisms. Here, the authors unravel the contribution of a stress-responsive pathway to RSTS where impaired HSF2 acetylation, due to RSTS-associated CBP/EP300 mutations, alters the expression of neurodevelopmental players, in keeping with hallmarks of cell-cell adhesion defects.
- Aurélie de Thonel
- , Johanna K. Ahlskog
- & Valérie Mezger
-
Article
| Open Access
Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb
New olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb circuits throughout life. Here, the authors show that immature OSNs provide behaviourally relevant sensory input to olfactory bulb neurons that is functionally distinct from that provided by mature OSNs.
- Jane S. Huang
- , Tenzin Kunkhyen
- & Claire E. J. Cheetham
-
Article
| Open Access
MTG8 interacts with LHX6 to specify cortical interneuron subtype identity
There is a large diversity of inhibitory interneurons in the mammalian cerebral cortex. How this emerges during embryogenesis remains unclear. Here, the authors identify MTG8 as a co-factor of LHX6 and a new regulator of cortical interneuron development.
- Zeinab Asgarian
- , Marcio Guiomar Oliveira
- & Nicoletta Kessaris
-
Article
| Open Access
Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks
Traumatic brain injury can cause long-term disability and thus constitutes a substantial healthcare burden worldwide. Here, the authors report a conductive microporous hydrogel to improve angiogenesis and recovery of brain function in traumatic brain lesions.
- Ru-Siou Hsu
- , Ssu-Ju Li
- & Shang-Hsiu Hu
-
Article
| Open Access
Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis
The mechanisms that govern cell fate decisions of postmigratory cranial neural crest cells remain largely unknown. Here the authors present a spatiotemporal single-cell regulatory atlas tracking these cells’ dental lineage diversification.
- Junjun Jing
- , Jifan Feng
- & Yang Chai
-
Article
| Open Access
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex
HNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes.
- Tamar Sapir
- , Aditya Kshirsagar
- & Orly Reiner
-
Article
| Open Access
An epigenome atlas of neural progenitors within the embryonic mouse forebrain
The authors took a multimodal approach to characterize the differential transcriptome and epigenetic landscape between distinct regions of the embryonic mouse forebrain, revealing many unexplored presumptive promoter-enhancer interactions.
- Christopher T. Rhodes
- , Joyce J. Thompson
- & Timothy J. Petros
-
Article
| Open Access
Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery
Stem cell based replacement therapies could provide a treatment for Parkinson’s disease. Here the authors outline a retinoic acid-based approach for robust derivation of dopamine neurons from stem cells that restore motor deficits in parkinsonian rats.
- Zhanna Alekseenko
- , José M. Dias
- & Johan Ericson
-
Article
| Open Access
Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development
The Dlgap protein family members are known for their role in synapses. Here the authors reveal important involvement in earlier steps of brain development, identifying DLGAP4 mutations in patients with cortical malformations, and also demonstrating a role in progenitors and migrating neurons.
- Delfina M. Romero
- , Karine Poirier
- & Fiona Francis
-
Article
| Open Access
Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Mitochondrial deficiency causes rare incurable disorders. Here, the authors use C. elegans to study these diseases and find that the natural compound lutein prevents neurodevelopmental deficits, thus pointing to a possible therapeutic target for the human diseases.
- Silvia Maglioni
- , Alfonso Schiavi
- & Natascia Ventura
-
Article
| Open Access
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Rawat et al. demonstrate that activation of adult-born immature hippocampal neurons is necessary and sufficient for the acute antidepressant effects of low-dose ketamine in mice.
- Radhika Rawat
- , Elif Tunc-Ozcan
- & John A. Kessler
-
Article
| Open Access
Reduced chromatin accessibility correlates with resistance to Notch activation
Notch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chromatin remodelling interact to direct differential gene expression during differentiation.
- Jelle van den Ameele
- , Robert Krautz
- & Andrea H. Brand
-
Article
| Open Access
A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing
During development, neural progenitors generate a variety of neural types sequentially. Here the authors examine gene expression patterns in Drosophila neural progenitors at single-cell level, and identify a gene regulatory network controlling the sequential generation of different neural types.
- Hailun Zhu
- , Sihai Dave Zhao
- & Xin Li
-
Article
| Open Access
Precision of morphogen gradients in neural tube development
Morphogen gradients encode positional information during development. Here the authors use theory and simulations to suggest a positional accuracy of single gradients that directly explains the observed precision of progenitor domain boundaries.
- Roman Vetter
- & Dagmar Iber
-
Article
| Open Access
Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors
The decline in neurogenesis following birth is accompanied with a quiescent state characteristic of neural progenitors of the adult brain. Here, the authors identify the Wnt pathway antagonist SFRP1 as a potential signal that promotes quiescence and show that its inhibition stimulates stem cell activation.
- Vanessa Donega
- , Astrid T. van der Geest
- & Elly M. Hol
-
Article
| Open Access
The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development
Neural cell type diversification during development is a complex and highly regulated process. Here, the authors show that the histone H3-lysine 27 demethylase Kdm6b promotes and inhibits the generation of specific motor neuron subtypes during the development of the mouse spinal cord.
- Wenxian Wang
- , Hyeyoung Cho
- & Soo-Kyung Lee
-
Article
| Open Access
Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells
The temporal development of tissues and organs may be defined by the genome-wide epigenetic and transcriptional state functioning as the clock. Here the authors found that Fbl, a ribosomal RNA methyltransferase, potentially behaves as a clock during neural stem cell (NSC) development by controlling translational efficiencies of epigenetic modifiers in the cerebral cortex primordium.
- Quan Wu
- , Yuichi Shichino
- & Fumio Matsuzaki
-
Article
| Open Access
Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
The evolutionary point where chromatin modifier function integrated into regulation of specific cell types is unclear. In the cnidarian Nematostella vectensis, the authors here show that lysine specific demethylase Lsd1 is developmentally regulated and required for normal development including cnidocyte differentiation.
- James M. Gahan
- , Ian U. Kouzel
- & Fabian Rentzsch
-
Article
| Open Access
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disorders and cognition revealing a convergence on transcriptional programs regulating excitatory cortical neurogenesis.
- Bret Sanders
- , Daniel D’Andrea
- & Eunju Shin
-
Article
| Open Access
Identification of a modular super-enhancer in murine retinal development
Super-enhancers are regions of genomic DNA comprised of multiple putative enhancers that contribute to dynamic gene expression patterns during development. Here the authors identify a modular super-enhancer in murine retinal development and show that distinct modules are responsible for retinal progenitor cell proliferation during early and bipolar neuron genesis during late retinal development.
- Victoria Honnell
- , Jackie L. Norrie
- & Michael A. Dyer
-
Article
| Open Access
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains
Ambient temperature significantly affects embryogenesis, but adaptive molecular mechanisms that respond to temperature remain unclear. Here, the authors identified species-specific thermal sensitivity of Notch signaling in developing amniote brains.
- Tadashi Nomura
- , Kohjiro Nagao
- & Katsuhiko Ono
Regional patterns of human cortex development correlate with underlying neurobiology