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Chromosomes are cellular structures that contain the genetic material. A chromosome is comprised of a single DNA molecule that may be either circular or linear. The full complement of a cells chromosomes is called the genome.
Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.
Telomere shortening causes replicative senescence but affects population growth in a complex manner. Here, the authors develop a mathematical model calibrated on yeast single-cell data which simulates cell populations undergoing senescence to gain insights into structural and dynamic properties.
Telomeres and centromeres are specialized chromosomal regions with distinct functions. Here, the authors uncover a long-distance molecular communication between these key regions, coordinating the formation of the telomere bouquet and the initiation of the meiotic program.
The Sc2.0 project involved synthesis and debugging of 16 chromosomes, and a tRNA neochromosome. Here the authors descript the SynXVI project, accompanied by an analysis of how similar projects could operate with hindsight and newly available technologies, and lessons learned from Sc2.0.
To investigate chromosomal segregation abnormalities that cause miscarriages, we developed a technique to isolate micronuclei derived from abnormal chromosomes from two-cell stage embryos and successfully analyzed these chromosomes.
Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.
In this Tools of the Trade article, Carly Tyer describes the development of Telo-seq, a method to enrich and sequence all telomeres within a sample, and highlights its use in distinguishing between the two telomere maintenance mechanisms used in cancer cells.
In this Journal Club article, Laura Ross discusses several seminal papers that describe the discovery of germline-specific chromosomes and paternal genome elimination, striking examples of non-Mendelian genetics.
Logsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative analyses of the variation in tandemly repeating α-satellite DNA.
