Nature

Cell signalling articles from across Nature Portfolio

Cell signalling is the mechanism by which stimuli are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Types of cell signalling pathways include checkpoint signalling, lipid signalling, growth signalling, nutrient signalling, insulin signalling, stress signalling, morphogen signalling, Hippo signalling, TOR signalling and integrin signalling.

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Transcriptional pausing as a molecular mechanism of sprouting angiogenesis

In-depth in vivo and in vitro functional analyses, along with a series of genomic assays, reveal RNF20 as a molecular rheostat controlling the balance between endothelial VEGF and Notch signaling during sprouting angiogenesis.
- Inês Cebola
- Graeme M. Birdsey
- Anna M. Randi
News & Views07 Oct 2024 Nature Cardiovascular Research
Volume: 3, P: 1184-1186

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Proteogenomic analysis dissects early-onset breast cancer patients with prognostic relevance
- Kyong-Ah Yoon
- Youngwook Kim
- Sun-Young Kong
ResearchOpen Access01 Nov 2024 Experimental & Molecular Medicine
P: 1-13
The MCP-3/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation
- Jung Ha Kim
- Kabsun Kim
- Nacksung Kim
ResearchOpen Access01 Nov 2024 Experimental & Molecular Medicine
P: 1-10
CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

Dinakaran et al. show that arteriovenous malformations in hereditary hemorrhagic telangiectasia are caused by CDK6-mediated cell cycle acceleration in response to BMP9/BMP10 inhibition and that CDK4/6 inhibitors can prevent the development of the disease.
- Sajeth Dinakaran
- Sima Qutaina
- Philippe Marambaud
Research01 Nov 2024 Nature Cardiovascular Research
P: 1-17
Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells
- Ahreum Baek
- Dawoon Baek
- Sung-Rae Cho
ResearchOpen Access30 Oct 2024 Scientific Reports
Volume: 14, P: 26076
Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells

Branched-chain α-ketoacids are shown to aerobically activate HIF1α signalling, which induces a phenotypic switch in vascular smooth muscle cells that is potentially relevant in the context of pulmonary artery hypertension.
- Wusheng Xiao
- Nishith Shrimali
- Joseph Loscalzo
Research29 Oct 2024 Nature Metabolism
P: 1-19
Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses

How caspases are differentially regulated in non-apoptotic stress responses remains enigmatic. Here, the authors show that Xeroderma pigmentosum protein XPD promotes stress specific caspase expression to balance genotoxic and non-genotoxic responses.
- Hai Wei
- Yi M. Weaver
- Benjamin P. Weaver
ResearchOpen Access29 Oct 2024 Nature Communications
Volume: 15, P: 9344

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News and Comment

Structure basis of ligand recognition and activation of GPR55
- Hao Chang
- Xiaoting Li
- Tian Hua
Correspondence31 Oct 2024 Cell Research
P: 1-4
Structural insight into GPR55 ligand recognition and G-protein coupling
- Ruixue Xia
- Qingning Yuan
- Yuanzheng He
CorrespondenceOpen Access31 Oct 2024 Cell Research
P: 1-4
IGF2-produced microRNA restricts growth via suppression of IGF1
- Olivia Tysoe
Research Highlights15 Oct 2024 Nature Reviews Endocrinology
P: 1
Fine-tuning protein hunger: sex- and mating-dependent setpoint control
- Yangkyun Oh
- Won-Jae Lee
Research Highlights14 Oct 2024 Cell Research
P: 1-2
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
- Benoit Viollet
- Bruno Guigas
Research Highlights14 Oct 2024 Cell Research
P: 1-2
Transcriptional pausing as a molecular mechanism of sprouting angiogenesis

In-depth in vivo and in vitro functional analyses, along with a series of genomic assays, reveal RNF20 as a molecular rheostat controlling the balance between endothelial VEGF and Notch signaling during sprouting angiogenesis.
- Inês Cebola
- Graeme M. Birdsey
- Anna M. Randi
News & Views07 Oct 2024 Nature Cardiovascular Research
Volume: 3, P: 1184-1186

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