Joint innervated by neurons

An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis

  • Zoe Rutter-Locher
  • Bruce W. Kirkham
  • Franziska Denk
Review Article

Featured

  • Epstein–Barr virus (EBV) infection is associated with numerous autoimmune diseases, including rheumatic diseases. In this Review, Robinson and colleagues provide an overview of the biology of EBV, the potential mechanisms through which EBV could promote autoimmune diseases and how EBV might be targeted for the treatment of autoimmune disease.

    • William H. Robinson
    • Shady Younis
    • Tobias V. Lanz
    Review Article

  • Holers and colleagues review current data linking immune mechanisms and dysbiosis at distinct mucosal sites to risk of rheumatoid arthritis (RA). Their newly introduced causal mucosal endotypes hypothesis suggests that lung-, gut-, or oral-associated endotypes might drive the pathogenesis and progression of RA, and highlights associated research directions towards preventive and therapeutic strategies in RA.

    • V. Michael Holers
    • Kristen M. Demoruelle
    • Kevin D. Deane
    Review Article

  • Type I interferon has a crucial role in the immunopathogenesis of systemic lupus erythematosus (SLE). Analysis of CD4+ T cells from individuals with SLE now shows that type I interferon intervenes with the transcriptional regulators AHR and JUN to downregulate expression of IL-22, which promotes tissue regeneration, and upregulate the expression of CXCL13, which supports lymphoid structure formation.

    • Mehrdad Pazhouhandeh
    • Di Yu
    News & Views

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Volume 20 Issue 11
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Announcements

  • A crowd of people with two individuals highlighted in a different colour

    Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.

  • Paper boats seen through a spyglass

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field

  • Knee x-ray of a 60 year old woman showing degenerative joint disease from osteoarthritis

    Osteoarthritis (OA) is a degenerative joint disease that leads to pain, stiffness and loss of function. It is the most common form of arthritis and one of the most prevalent musculoskeletal disorders worldwide. This collection from Nature Reviews Rheumatology brings together articles discussing the latest insights into the pathogenesis and management of OA.

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Latest Reviews & Analysis

    • Digital health has the potential to improve patient care in rheumatology and alleviate strain on the health-care system. This Review explores the current status of the transition from traditional health care to a model that harnesses the potential of digital health technologies, including discussion of the main benefits and barriers.

      • Johannes Knitza
      • Latika Gupta
      • Thomas Hügle
      Review Article

    • In this Review, López and Gualillo discuss the complex interrelationships between rheumatic diseases and the hypothalamic and autonomic mechanisms that regulate metabolism, and explore the therapeutic potential of targeting central regulators of energy balance.

      • Miguel López
      • Oreste Gualillo
      Review Article

    • Despite the availability of numerous treatment options, the management of rheumatoid arthritis remains suboptimal. In this Review, Konzett and Aletaha discuss strategies to advance clinical decision-making from trial-and-error to an informed process that considers more than just drug efficacy, and appropriately balances effort and success.

      • Victoria Konzett
      • Daniel Aletaha
      Review Article

    • This Review discusses the involvement of early-stage and late-stage somatic mutations in the pathogenesis of both monogenic and multifactorial rheumatic diseases. The authors highlight new methods of detecting low-frequency variants and the implications for diagnosis and treatment in patients with rheumatic diseases.

      • Sofia Torreggiani
      • Flore S. Castellan
      • David B. Beck
      Review Article

    • Epstein–Barr virus (EBV) infection is associated with numerous autoimmune diseases, including rheumatic diseases. In this Review, Robinson and colleagues provide an overview of the biology of EBV, the potential mechanisms through which EBV could promote autoimmune diseases and how EBV might be targeted for the treatment of autoimmune disease.

      • William H. Robinson
      • Shady Younis
      • Tobias V. Lanz
      Review Article

News & Comment

  • Findings from an observational study suggest that the frequency of uveitis in patients with spondyloarthritis has declined since the introduction of biologic DMARDs.

    • Sarah Onuora
    Research Highlight

  • Synovial fibroblasts from individuals with OA release small extracellular vesicles with potentially pathogenic miRNA cargo.

    • Maria Papatriantafyllou
    Research Highlight

  • Consistent with findings from clinical trials, in a retrospective cohort study, Janus kinase inhibitors improved pain associated with rheumatoid arthritis as well as or better than biologic DMARDs in clinical practice.

    • Sarah Onuora
    Research Highlight

Collections

Keys with joints in the key heads

Key Advances in Rheumatology

The Key Advances in Rheumatology collection offers expert insight into the most important discoveries made each year, and is an essential resource for students, physicians and clinical researchers.
  • Sarah Onuora
Collection

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