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This Comment discusses erroneous reporting of mass spectrometry analyses of lipids in mammalian samples, and provides recommendations for how to avoid it.
Robert Parton and colleagues discuss novel evidence on the role of dynamin in caveolar endocytosis, which calls into question established models of dynamin-mediated fission.
Thomas Arnesen and colleagues discuss an emerging major role of one of the most common protein modifications, N-terminal acetylation, in shielding the proteome from degradation.
Recent studies show that antigenic peptides are derived from the translation of precursor mRNAs. Robin Fåhraeus argues that it is therefore time to re-evaluate nuclear translation and its interesting implications.
Quality control of misfolded glycosylphosphatidylinositol-anchored proteins (GPI-APs) does not occur through ER-associated degradation, as the lipid anchor precludes retrotranslocation across the ER membrane. Instead, different organisms have developed distinct solutions to prevent the accumulation of misfolded GPI-APs.
Numerous databases collate data on long non-coding RNAs (lncRNAs); Ma and Zhang describe their range and discuss their contribution to lncRNA research.
In this Comment, the authors draw attention to non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence and voice the need for caution in using BCL-2 inhibitors as senolytics.
Fleming and Burrows discuss similarities between a gene-regulating DNA modification and a mutagenic one, which share a common intermediate when removed through base excision repair.
In response to tissue damage in adults, embryonic gene expression programmes are reactivated to enhance repair. Hassan Fazilaty describes a correlation between damage extent and how early in embryogenesis the restored expression programme is.
Oded Rechavi and Pavel Tomancak suggest a new approach to ascribing authorship in scientific papers that specifies who thought of each idea, who ran each experiment and who analysed the data.
This Comment draws attention to cellular protrusions as a source of extracellular vesicles (EVs). These protrusion-derived vesicles expand the repertoire of EVs, impacting current nomenclature and our understanding of EV functions in inter-cellular communication.
Bishop and Hawley argue against a direct relationship between changes in mRNA levels and the abundance of the proteins they encode in skeletal muscles in response to exercise.
Kempson and colleagues suggest that existing imaging assays do not quantitatively represent double-strand DNA breaks, and urge the development of more accurate assays.
