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In this Tools of the Trade article, Takamasa Kudo (in the Aviv Regev lab, in collaboration with Eric Lubeck) describes how PerturbView enables robust visualization of many thousands of genetic perturbations.
A preprint by Laubreton et al. suggests a role for agonist selection and cytokine-driven bystander activation in the differentiation and recruitment of memory-phenotype Ly49+CD8+ T cells.
In this Tools of the Trade article, Sarah Al Abdullatif describes a method to measure — in a physiological context — mechanical forces transmitted between a T cell receptor and its ligand.
Recent studies in mouse models of viral infection showed that precursors of terminally exhausted T cells emerge early during the course of disease. Here, Galluzzi discusses these findings and what they may mean for our understanding of tumour immunology and responses to immunotherapy with immune checkpoint blockade.
Hsu et al. report in Cell that the release of complement-inhibiting vesicles by neutrophils as they age is a self-resolving, anti-inflammatory mechanism that supports a return to homeostasis.
A study in Science Immunology shows that meningeal regulatory T (Treg) cells limit the activation, proliferation and parenchymal infiltration of T cells and NK cells, indicating that Treg cells act as gatekeepers of the brain.
Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus for cardiovascular disease.
To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism and compromises their antitumour activity.
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
A study in Science reports that intestinal innate lymphoid cells migrate to the pancreas in response to low blood glucose levels to promote glucagon production.
In this Tools of the Trade article, Yishay Pinto describes a tool, called Phanta, that profiles phages alongside their bacterial hosts in microbiome analysis.
A phenomenon called 'autosomal random monoallelic expression' (aRMAE) may explain phenotypic variability of clinical disease in carriers of mutations that cause inborn errors of immunity.
A study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce pyroptotic cell death in bystander cells.
