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Machine learning in genomics

This Nature Reviews Genetics collection brings together Reviews by key opinion leaders that explain cutting-edge machine learning methodology and how these tools are being applied in genomics. 

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  • Stylized multi-coloured Circos plot

    This Nature Milestone provides a perspective of major genomic sequencing-related developments in the 21st century — from the first human reference genome, through methodological breakthroughs, to the impact of sequencing on fields as diverse as microbiology, cancer and palaeogenetics.

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    This Nature Reviews Genetics collection brings together Reviews written by key opinion leaders on single-cell omics methods and applications.

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    The editors of Nature Reviews Genetics will be posting about the latest developments in research and policy, and providing news about the journal. If you have any questions or feedback for us, get in touch by email or on X.

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    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews Genetics can help you stay up-to-date, and visit Nature Reviews for more.

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  • In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes underlying recurrent phenotypic evolution in stickleback fish.

    • Julie Jung
    • Thomas King
    Journal Club
  • Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene expression in budding yeast, and the GTEx atlas of genetic regulatory effects across human tissues inspired the FarmGTEx project to accelerate precision agriculture.

    • Lingzhao Fang
    Journal Club
  • Rahimzadeh et al. discuss the ethical, legal and social implications of storing and analysing human genomic data in the cloud and provide recommendations and new research directions for future, trustworthy cloud-based genomic data access and management.

    • Vasiliki Rahimzadeh
    • Sarah C. Nelson
    • Stephanie M. Fullerton
    Comment
  • In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20th century, which posited that metabolic gradients drive cellular differentiation and tissue patterning.

    • Berna Sozen
    Journal Club

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