Nature Biotechnology

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Sparse, reliable biomarker discovery

Current issue

AI meets real-world patients

Editorial07 Oct 2024
TCR cell therapies vanquish solid tumors — finally

Charlotte Harrison
News02 Oct 2024
Bispecific upstages Keytruda

News in Brief14 Oct 2024
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes

Bart Keymeulen
Kaat De Groot
Daniel Pipeleers
ArticleOpen Access27 Nov 2023
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

Emiliano Hergenreder
Andrew P. Minotti
Lorenz Studer
ArticleOpen Access02 Jan 2024
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Meirui An
Aditya Raguram
David R. Liu
ArticleOpen Access08 Jan 2024

Contents

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Announcements

Foundation models build on ChatGPT technology

Scientists are using ever more sophisticated AI algorithms trained on vast, unlabeled datasets to develop models that can ‘interpret’ biological data to help guide biomolecule design.
From Bench to Podcast: Stories from Biotech Labs

On this episode, Associate Editor Cláudia Vilhena interviews Nicoletta Cieri, first author of an article showing how a devised analytic framework can aid the prevention of post-transplant disease recurrence. Nicoletta and Cláudia explore the highlights of the story, discuss the future of individualized medicine and touch base on future career opportunites for postdocs.
Generative AI platforms drive drug discovery dealmaking

From Biopharma Dealmakers: Companies developing artificial intelligence-based platforms that enable the design of small-molecule and biologic drug candidates have been a focus of biopharma dealmaking in the past year.
Read the September issue of Biopharma Dealmakers

Our latest issue includes company profiles and editorial pieces covering innovations in oncology, CNS and artificial intelligence.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.

Josh Tycko
Mike V. Van
Michael C. Bassik
Article01 Nov 2024
A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection

ReChb is a Cas12a nuclease with expanded target access and substrate recognition.

Ylenia Jabalera
Igor Tascón
Raul Perez-Jimenez
Article31 Oct 2024
Comprehensive genome analysis and variant detection at scale using DRAGEN

DRAGEN rapidly identifies diverse types of genetic variants.

Sairam Behera
Severine Catreux
Fritz J. Sedlazeck
ArticleOpen Access25 Oct 2024
A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations

Protein–protein interactomes incorporating structural data predict the functional consequences of disease mutations.

Dapeng Xiong
Yunguang Qiu
Haiyuan Yu
Article24 Oct 2024
Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors

Gold-siRNA clusters boost the immune response of radiotherapy against primary and distant tumors.

Yuyan Jiang
Hongbin Cao
Quynh-Thu Le
Article24 Oct 2024
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues

Chromatin organization is measured in single cells using droplet microfluidics.

Lei Chang
Yang Xie
Bing Ren
ArticleOpen Access18 Oct 2024

Latest Reviews & Analysis

- An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
  
  We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, transcriptomics and mass spectrometry-based immunopeptidomics. NeoDisc accurately identifies and prioritizes tumor-specific antigens and designs personalized cancer vaccines. The pipeline reveals tumor heterogeneity and emphasizes defects in antigen presentation that might affect the success of cancer immunotherapy.
  
  Research Briefing11 Oct 2024
- Advances in optical pooled screening to map spatial complexity
  
  Two major advances in optical pooled screening improve substantially on sensitivity and robustness, expanding its applicability to a broader range of biological contexts.
  Maurice Kahnwald
  Marius Mählen
  Prisca Liberali
  
  News & Views07 Oct 2024
- A framework for expanding discovery efforts with compressed phenotypic screens
  
  Sample, financial and labor requirements are key barriers to scaling up high-content phenotypic discovery efforts. A broadly applicable method overcomes these challenges through experimental compression (by pooling various perturbations) and computational deconvolution (of their individual effects), empowering the use of phenotypic screening to advance therapeutic discovery.
  
  Research Briefing07 Oct 2024
- A CRISPR-based method for detecting mRNA in extracellular vesicles
  
  A CRISPR-based assay both recognizes and amplifies target mRNA, achieving sub-attomolar sensitivity with single-nucleotide resolution. This method enables the detection of low-abundance mRNA in extracellular vesicles, providing clinically relevant information for precision oncology.
  
  Research Briefing07 Oct 2024
- Bacteria displaying cytokines heat up the tumor microenvironment
  
  Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector cells.
  Marine Fidelle
  Laurence Zitvogel
  
  News & Views04 Oct 2024
- Building better mRNA for therapeutics
  Bei Liu
  Tao Pan
  
  News & Views23 Sept 2024
- Targeting double-stranded nucleic acids using the λExo–pDNA system
  
  Research Briefing18 Sept 2024
- A developmental route to hematopoietic stem cells
  Adam C. Wilkinson
  Marella F. T. R. de Bruijn
  
  News & Views18 Sept 2024
- Recoded gene circuits for multiplexed genetic code expansion
  
  Research Briefing11 Sept 2024

News & Comment

Pest control gets the CRISPR treatment

Precision genetic methods are enabling more efficient, environmentally friendly pest control methods for agricultural use as well as stopping the spread of disease.

Caroline Seydel
News Feature23 Oct 2024
A strategy to load, rethread and read protein sequences through a nanopore

Iris Marchal
Research Highlight14 Oct 2024
Niemann–Pick double win

News in Brief14 Oct 2024
T cells

Recent patents relating to the manufacture, preparation and use of T cells in treating cancer.

Patents14 Oct 2024
Cellular shuttles put mislocalized proteins in their right place

Iris Marchal
Research Highlight14 Oct 2024
Bispecific upstages Keytruda

News in Brief14 Oct 2024

Collections

Navigating the vaccines landscape

We explore the latest developments in the vaccines field, through our editorial feature and showcase of companies.

Collection 03 Jun 2024

Trending - Altmetric

Science jobs

Call for Global Talents! 2024 SIAT-IBT Forum Announcement

We are seeking leading academic talents and young leading talents.

Shenzhen, Guangdong, China

Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences（CAS)
Instructional Faculty Positions

The Biological and Environmental Science and Engineering (BESE) Division at King Abdullah University of Science and Technology (KAUST), a globally ...

Saudi Arabia (SA)

King Abdullah University of Science and Technology
Career Opportunities at the Yazhouwan National Laboratory, Hainan, China

YNL recruits leading scientists in agriculture: crop/animal genetics, biotech, photosynthesis, disease resistance, data analysis, and more.

Sanya, Hainan, China

Yazhouwan National Laboratory
Faculty Positions at the Mechano-X Institute (THUM), Tsinghua University

Interdisciplinary faculty positions at the Mechano-X Institute (THUM), Tsinghua University, all levels from Assistant, Associate to Full Professors.

Beijing (CN)

Tsinghua University - Mechano-X Institute
Scientist / Postdoc (m/f/d)

The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes ...

Germany (DE)

Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.

Announcements

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First self-amplifying mRNA vaccine approved

Wearable biosensors for healthcare monitoring

Comprehensive genome analysis and variant detection at scale using DRAGEN

A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations

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