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The dual effects of glucocorticoids (GCs) are illustrated by bees. Left, low levels of GCs bind to the canonical high-affinity GC receptor (GR, the flower producing honey), mediating physiological and therapeutic effects. Right, high levels of GCs can also bind to the low-affinity receptor, tau, leading to bone loss and demonstrating pathological effects. See page 23–44 by Wenyu Fu et al. for details.