Reward signaling via dopamine is most commonly thought of as acting through neurons expressing either D1 or D2 dopamine receptors. Enriquez-Traba et al. show that neurons in the ventral striatum co-express D1 and D3 receptors, which they use to signal dissociable aspects of reward.
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References
Berke, J. D. Nat. Neurosci. 21, 787–793 (2018).
Sippy, T. & Tritsch, N. X. Trends Neurosci. 46, 228–239 (2023).
Enriquez-Traba, J. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01819-9 (2024).
Ridray, S. et al. Eur. J. Neurosci. 10, 1676–1686 (1998).
Pribiag, H. et al. Neuron 109, 2165–2182.e10 (2021).
Nelson, A. B. & Kreitzer, A. C. Annu. Rev. Neurosci. 37, 117–135 (2014).
Tritsch, N. X. & Sabatini, B. L. Neuron 76, 33–50 (2012).
Tewson, P. H., Martinka, S., Shaner, N. C., Hughes, T. E. & Quinn, A. M. J. Biomol. Screen. 21, 298–305 (2016).
Dobbs, L. K. et al. Neuron 90, 1100–1113 (2016).
Diaz, J. et al. J. Neurosci. 20, 8677–8684 (2000).
Dreyer, J. K., Herrik, K. F., Berg, R. W. & Hounsgaard, J. D. J. Neurosci. 30, 14273–14283 (2010).
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Tritsch, N.X. Motivating interest in D3 dopamine receptors. Nat Neurosci 28, 6–7 (2025). https://doi.org/10.1038/s41593-024-01820-2
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DOI: https://doi.org/10.1038/s41593-024-01820-2
