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Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

Nature volume 348, pages 411–418 (1990)Cite this article

Abstract

The structure of an N-terminal fragment of CD4 has been determined to 2.4 Å resolution. It has two tightly abutting domains connected by a continuous β strand. Both have the immunoglobulin fold, but domain 2 has a truncated β barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocom-patibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Jiahuai Wang, Youwei Yan, Thomas P. J. Garrett, Jinhuan Liu, David W. Rodgers & Stephen C. Harrison

  2. Howard Hughes Medical Institute, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Youwei Yan, Thomas P. J. Garrett & Stephen C. Harrison

  3. Upjohn Company, Kalamazoo, Minnesota, 49007, USA

    Robert L. Garlick

  4. Laboratory of Immunobiology, Dana Farber Cancer Institute,

    George E. Tarr, Yasmin Husain & Ellis L. Reinherz

  5. Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 02115, USA

    Ellis L. Reinherz

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  1. Jiahuai Wang
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Wang, J., Yan, Y., Garrett, T. et al. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 348, 411–418 (1990). https://doi.org/10.1038/348411a0

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