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A tissue-specific endothelial cell molecule involved in lymphocyte homing

Nature volume 331, pages 41–46 (1988)Cite this article

Abstract

An endothelial cell surface molecule that is selectively expressed in mucosal organs is required for lymphocyte homing to mucosal lymphoid tissues. This 'vascular addressin' appears to function as a tissue-specific marker or address signal for recognition by lymphocytes circulating in the blood.

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References

  1. Alby, L. & Auerbach, R. Proc. natn. Acad. Sci. U.S.A. 81, 5739–5743 (1984).

    Article  ADS  CAS  Google Scholar 

  2. Auerbach, R. et al. Cancer Res. 47, 1492–1596 (1987).

    CAS  PubMed  Google Scholar 

  3. Bargatze, R. F., Wu, N. W., Weissman, I. L. & Butcher, E. C. J. exp. Med. 166, 1125–1131 (1987).

    Article  CAS  Google Scholar 

  4. Gordon, S. J. Cell Sci. Suppl. 4, 267–286 (1986).

    Article  CAS  Google Scholar 

  5. Lewinsohn, D. M., Bargatze, R. F. & Butcher, E. C. J. lmmun. 138, 4313–4321 (1987).

    CAS  Google Scholar 

  6. Gowans, J. L. & Knight, E. J. Proc. R. Soc. B159, 257–282 (1964).

    ADS  CAS  Google Scholar 

  7. Marchesi, V. T. & Gowans, J. L. Proc. R. Soc. B159, 283–290 (1964).

    ADS  CAS  Google Scholar 

  8. Guy-Grand, D., Griscelli, C. & Vassalli, P. Eur. J. Immun. 4, 435–443 (1974).

    Article  CAS  Google Scholar 

  9. McWilliams, M., Phillips-Quagliata, J. M. & Lamm, M. E. J. exp. Med. 145, 866–875 (1977).

    Article  CAS  Google Scholar 

  10. Rose, M. L., Parrott, D. M. V. & Bruce, R. G. Immunology 35, 415–423 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Hall, J. G., Hopkins, J. & Orlans, E. Eur. J. lmmun. 7, 30–37 (1979).

    Article  Google Scholar 

  12. Cahill, R. N. P., Poskitt, D. C., Frost, H. and Trnka, A. J. exp. Med. 145, 420–428 (1977).

    Article  CAS  Google Scholar 

  13. Smith, M. E., Martin, A. F. & Ford, W. L. Monogr. Allergy 16, 203–232 (1980).

    CAS  PubMed  Google Scholar 

  14. Chin, W. & Hay, J. B. Gastroenterology 79, 1231–1242 (1980).

    CAS  PubMed  Google Scholar 

  15. Butcher, E. C. Curr. Topics Microbiol. Immun. 128, 85–122 (1986).

    Article  CAS  Google Scholar 

  16. Butcher, E. C., Scollay, R. G. & Weissman, I. L. Eur. J. Immun. 10, 556–561 (1980).

    Article  CAS  Google Scholar 

  17. Chin, Y. H., Rasmussen, R., Cakiroglu, A. G. & Woodruff, J. J. J. Immun. 133, 2961–2965 (1984).

    CAS  PubMed  Google Scholar 

  18. Jalkanen, S., Steere, A. C., Fox, R. I. & Butcher, E. C. Science 233, 556–558 (1986).

    Article  ADS  CAS  Google Scholar 

  19. Gallatin, W. M., Weissman, I. L. & Butcher, E. C. Nature 303, 30–34 (1983).

    Article  ADS  Google Scholar 

  20. Chin, Y. H., Rasmussen, R. R., Woodruff, J. J. & Easton, T. G. J. Immun. 136, 2556–2561 (1986).

    CAS  PubMed  Google Scholar 

  21. Jalkanen, S., Bargatze, R. F., Herron, L. & Butcher, E. C. Eur. J. Immun. 16, 1195–1202 (1986).

    Article  CAS  Google Scholar 

  22. Jalkanen, S. T., Bargatze, R. F., de los Toyos, J. & Butcher, E. C. J. Cell Biol. 105, 983–990 (1987).

    Article  CAS  Google Scholar 

  23. Duijvestijn, A. M., Kerkhove, M., Bargatze, R. F. & Butcher, E. C. J. Immun. 138, 713–719 (1987).

    CAS  PubMed  Google Scholar 

  24. Jeurissen, S. H. M., Duijvestijn, A. M., Sontag, Y. & Kraal, G. Immunology 62, 273–277 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Roux, M. E., McWilliams, M., Phillips-Quagliata, J. M., Weisz-Carrington, P. & Lamm, M. E. J. exp. Med. 146, 1311 (1977).

    Article  CAS  Google Scholar 

  26. Stamper, H. B. Jr & Woodruff, J. J. J. exp. Med. 144, 828–833 (1976).

    Article  Google Scholar 

  27. Butcher, E. C., Scollay, R. G. & Weissman, I. L. J. Immun. 123, 1996–2003 (1979).

    CAS  PubMed  Google Scholar 

  28. Stevens, S. K., Weissman, I. L. & Butcher, E. C. J. Immun. 128, 844–851 (1982).

    CAS  PubMed  Google Scholar 

  29. Edelman, G. M. Science 219, 450–457 (1983).

    Article  ADS  CAS  Google Scholar 

  30. Springer, T. A., Dustin, M. L., Kishimoto, T. K. and Marlin, S. D. A. Rev. Immun. 5, 223–252 (1987).

    Article  CAS  Google Scholar 

  31. Trisler, G. D., Schneider, M. D. & Nirenberg, M. Proc. natn. Acad. Sci. U.S.A. 78, 2145–2149 (1981).

    Article  ADS  CAS  Google Scholar 

  32. Schmitz, M., Nunez, D. & Butcher, E. C. Gastroenterology (in the press).

  33. McDermott, M. R. & Bienenstock, J. J. Immun. 122, 1892–1898 (1979).

    CAS  PubMed  Google Scholar 

  34. Stoolman, L. M. & Rosen, S. D. J. Cell Biol. 96, 722–729 (1983).

    Article  CAS  Google Scholar 

  35. Stoolman, L. M., Tenforde, T. & Rosen, S. D. J. Cell Biol. 99, 1535–1540 (1984).

    Article  CAS  Google Scholar 

  36. Rosen, S. D., Singer, M. S. & Yednock, T. A. Science 228, 1005–1007 (1985).

    Article  ADS  CAS  Google Scholar 

  37. Duijvestijn, A. M., Schreiber, A. B. & Butcher, E. C. Proc. natn. Acad. Sci. U.S.A. 83, 9114–9118 (1986).

    Article  ADS  CAS  Google Scholar 

  38. Laemmli, V. K. Nature 227, 680–685 (1970).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford, California, 94305, USA

    Philip R. Streeter, Ellen Lakey Berg, Bich Tien N. Rouse, Robert F. Bargatze & Eugene C. Butcher

  2. Veterans Administration Medical Center, Palo Alto, California, 94304, USA

    Philip R. Streeter, Ellen Lakey Berg, Bich Tien N. Rouse, Robert F. Bargatze & Eugene C. Butcher

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  1. Philip R. Streeter
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  2. Ellen Lakey Berg
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  4. Robert F. Bargatze
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  5. Eugene C. Butcher
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Streeter, P., Berg, E., Rouse, B. et al. A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature 331, 41–46 (1988). https://doi.org/10.1038/331041a0

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