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In vitro Cytotoxic Activity of Thymus Cells sensitized to Alloantigens

Nature volume 227, pages 72–73 (1970)Cite this article

Abstract

THE thymus plays an important part in the development of certain immune reactions. Neonatally thymectomized mice showed an impaired antibody response to heterologous erythrocytes and serum proteins1. Recent studies, have demonstrated that collaboration between thymus-derived cells and bone marrow-derived cells was essential for mice to respond to sheep red blood cells (SRBC) by producing haemolysin-forming cells2–4. Thymus-derived cells, although undergoing mitosis in response to the antigenic stimulus5, did not produce antibody6, but influenced bone marrow-derived precursor cells to differentiate into antibody-producing cells4.

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References

  1. Miller, J. F. A. P., and Osoba, D., Physiol. Rev., 47, 437 (1967).

    Article  CAS  Google Scholar 

  2. Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. Med., 122, 1167 (1966).

    Article  CAS  Google Scholar 

  3. Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).

    Article  CAS  Google Scholar 

  4. Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 821 (1968).

    Article  CAS  Google Scholar 

  5. Davies, A. J. S., Leuchars, E., Wallis, V., and Koller, P. C., Transplantation, 4, 438 (1966).

    Article  CAS  Google Scholar 

  6. Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).

    Article  Google Scholar 

  7. Brunner, K. T., Mauel, J., Cerottini, J.-C., and Chapuis, B., Immunology, 14, 181 (1967).

    Google Scholar 

  8. Brunner, K. T., Mauel, J., Rudolf, H., and Chapuis, B., Immunology (in the press).

  9. Martin, W. J., J. Immunol., 103, 979 (1969).

    CAS  PubMed  Google Scholar 

  10. Billingham, R. E., Ann. NY Acad. Sci., 73, 782 (1958).

    Article  ADS  CAS  Google Scholar 

  11. Vos, O., de Vries, J., Collenteur, J. C., and van Bekkum, D. W., J. Nat. Cancer Inst., 23, 53 (1959).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Swiss Institute for Experimental Cancer Research, CH-1011, Lausanne

    J.-C. CEROTTINI, A. A. NORDIN & K. T. BRUNNER

Authors
  1. J.-C. CEROTTINI
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  2. A. A. NORDIN
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  3. K. T. BRUNNER
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CEROTTINI, JC., NORDIN, A. & BRUNNER, K. In vitro Cytotoxic Activity of Thymus Cells sensitized to Alloantigens. Nature 227, 72–73 (1970). https://doi.org/10.1038/227072a0

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