You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without javascript enabled.

Search for Articles:

Title / Keyword

Author / Affiliation / Email

Journal

Article Type

Advanced Search

Section

Special Issue

Volume

Issue

Number

Page

Logical OperatorOperator

Search Text

Search Type

Journal Description

Life

Life is an international, peer-reviewed, open access journal of scientific studies related to fundamental themes in life sciences, from basic to applied research, published monthly online by MDPI. The Astrobiology Society of Britain (ASB) and Spanish Association for Cancer Research (ASEICA) are affiliated with Life and their members receive a discount on the article processing charges.

Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, CAPlus / SciFinder, AGRIS, and other databases.
Journal Rank: JCR - Q1 (Biology) / CiteScore - Q1 (Paleontology)
Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 18 days after submission; acceptance to publication is undertaken in 2.5 days (median values for papers published in this journal in the first half of 2024).
Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Testimonials: See what our editors and authors say about Life.
Companion journals for Life include: Physiologia and Hydrobiology.

Impact Factor: 3.2 (2023); 5-Year Impact Factor: 3.1 (2023)

Imprint Information Journal Flyer Open Access ISSN: 2075-1729

Latest Articles

12 pages, 964 KiB

Open AccessReview

Walnut Consumption May Contribute to Healthy Cardiovascular Endothelial Function by Maintaining Membrane Integrity

by Dora Jarai and Akos Koller

Life 2024, 14(11), 1426; https://doi.org/10.3390/life14111426 - 5 Nov 2024

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. A healthy diet has an important role in delaying the development of many modifiable risk factors of CVD, including abdominal obesity, high blood pressure, high plasma levels of cholesterol, and glucose. The consumption [...] Read more.

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. A healthy diet has an important role in delaying the development of many modifiable risk factors of CVD, including abdominal obesity, high blood pressure, high plasma levels of cholesterol, and glucose. The consumption of various nuts, especially walnuts, may benefit both primary and secondary prevention due to their bioactive components. This review focuses on (1) the protective role of walnut consumption on CVD at large (2) and the potential cellular and molecular mechanisms by which they have beneficial effects on vascular endothelial function. Walnuts contain many essential ingredients (such as polyunsaturated fatty acids, phenolic compounds, and vitamin E) necessary for the healthy functioning of membranes. Since membranes are involved in nearly all processes associated with life-related function, the main underlying mechanism of walnut-improved cardiovascular function is likely based on improving membrane composition and function by providing all of the substrates necessary for membranes, such as cell, mitochondria, Golgi, nucleus, and so on. In addition to endothelial cell function, all other cells and membranes are likely to benefit from walnut consumption, suggesting that incorporating walnuts into the human diet is essential, for example, during higher physical and mental demand, such as exercise, and may mitigate the risk for the development of cardiovascular diseases and compensate for the sedentary lifestyle, especially in those of an older age. Full article

(This article belongs to the Special Issue Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People)

► Show Figures

Figure 1

14 pages, 603 KiB

Open AccessReview

Extremophiles and Extremophilic Behaviour—New Insights and Perspectives

by George N. Angelakis, Chrysianna Psarologaki, Stergios Pirintsos and Kiriakos Kotzabasis

Life 2024, 14(11), 1425; https://doi.org/10.3390/life14111425 - 5 Nov 2024

Extremophiles, throughout evolutionary time, have evolved a plethora of unique strategies to overcome hardships associated with the environments they are found in. Modifying their genome, showing a bias towards certain amino acids, redesigning their proteins, and enhancing their membranes and other organelles with [...] Read more.

Extremophiles, throughout evolutionary time, have evolved a plethora of unique strategies to overcome hardships associated with the environments they are found in. Modifying their genome, showing a bias towards certain amino acids, redesigning their proteins, and enhancing their membranes and other organelles with specialised chemical compounds are only some of those strategies. Scientists can utilise such attributes of theirs for a plethora of biotechnological and astrobiological applications. Moreover, the rigorous study of such microorganisms regarding their evolution and ecological niche can offer deep insight into science’s most paramount inquiries such as how life originated on Earth and whether we are alone in the universe. The intensification of studies involving extremophiles in the future can prove to be highly beneficial for humanity, even potentially ameliorating modern problems such as those related to climate change while also expanding our knowledge about the complex biochemical reactions that ultimately resulted in life as we know it today. Full article

(This article belongs to the Special Issue Extremophiles Breakthrough: Hot Topics and Current Issues in Their Isolation, Identification and Biotechnological Applications)

► Show Figures

Figure 1

23 pages, 2602 KiB

Open AccessArticle

Assessing the Optimal Antibacterial Action of Lavandula stoechas L., Thymus zygis L., and Eucalyptus camaldulensis Dehnh Essential Oils

by Farah Aabouch, Saoussan Annemer, Badr Satrani, Ismail Ettaleb, Mohammed Kara, Mohamed Ghanmi, Abdelaaty Abdelaziz Shahat, Ravish Choudhary, Abdellah Farah, Mohamed Ouajdi and Jamila Dahmani

Life 2024, 14(11), 1424; https://doi.org/10.3390/life14111424 - 5 Nov 2024

The use of combined essential oils (EOs) is a new technique that can improve their preservative effects while minimizing their sensory impact in foods. The aim of this study was to determine the chemical profile of three essential oils (EOs) extracted from Lavandula [...] Read more.

The use of combined essential oils (EOs) is a new technique that can improve their preservative effects while minimizing their sensory impact in foods. The aim of this study was to determine the chemical profile of three essential oils (EOs) extracted from Lavandula stoechas L. (Ls), Thymus zygis L. (Tz), and Eucalyptus camaldulensis Dehnh (Ec) and to evaluate their synergistic antibacterial activity for optimal inhibition against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus using an augmented Simplex centroid mixing scheme. The essential oils were extracted by hydrodistillation and analyzed via gas chromatography–mass spectrometry. Anti-bacterial potency was evaluated by disk diffusion. Chemical analysis revealed the main compounds in Lavandula stoechas (Ls) essential oil: camphor (36.15%), followed by fenchone (16.57%) and Z-8-hydroxy linalool (8.28%). The Thymus zygis (Tz) essential oil is dominated by δ-terpineol (27.64%), δ-3-carene (15.7%), and thymol (14.17%). In contrast, the Eucalyptus camaldulensis (Ec) essential oil contains mainly 1,8-cineole (43.61%), γ-terpinene (11.71%), and α-terpineol (10.58%). The optimal mixture is the binary association of 40% E. camaldulensis EO and 60% T. zygis EO, which provides an effective inhibition diameter (ID) of 13.37 mm to inhibit S. aureus. Furthermore, the formulation of 27% and 73% EOs of E. camaldulensis and T. zygis, respectively, corresponds to the mixture required to achieve the optimum inhibition diameter (ID = 11.55 mm) against E. coli. In addition, the mixture of 29% EO of E. camaldulensis and 71% EO of T. zygis is the optimum mixture to inhibit B. subtilis, with an inhibition diameter of 12.31 mm. These findings highlight the potency of antibacterial formulations of these essential oils and suggest that they might be used as substitutes for conventional drugs to prevent the development of bacteria responsible for serious infections and food spoilage. Full article

(This article belongs to the Special Issue Advances in the Biomedical Applications of Plants and Plant Extracts)

► Show Figures

Figure 1

6 pages, 1250 KiB

Open AccessArticle

The Sternocleidomastoid Muscle Reverse Pad: A “Safety Net” in Catastrophic Tracheal Surgery Situation

by Sara Mantovani, Delia Giovanniello and Massimo O. Jaus

Life 2024, 14(11), 1423; https://doi.org/10.3390/life14111423 - 5 Nov 2024

Background: This paper presents the outcomes of employing the inferiorly based rotated sternocleidomastoid muscle flap in complex tracheal reconstruction/repair scenarios, focusing on the key objectives of ensuring stable airway, functional digestive tract and patient survival. Methods: A retrospective analysis was performed for patients [...] Read more.

Background: This paper presents the outcomes of employing the inferiorly based rotated sternocleidomastoid muscle flap in complex tracheal reconstruction/repair scenarios, focusing on the key objectives of ensuring stable airway, functional digestive tract and patient survival. Methods: A retrospective analysis was performed for patients treated at two medical centers (A.O. San Camillo Forlanini, Rome, and A.O.U. Careggi, Florence) from 2011 to 2023, in which the sternocleidomastoid muscle (SCM) flap, detached from the mastoid and basicranium, was rotated on the lower pivot directly onto the repair site and pedicled to the sternal origin to ensure the continuity of the airway. Average postoperative hospital stay, follow-up period and patient survival were analyzed. Follow-up assessments encompassed bronchoscopies and CT scans conducted at intervals of 15 and 28 days, and subsequently at 3 and 9 months. Results: A total of five patients were enrolled in this study. These cases included one patient with anterior tracheal wall lesions with abundant tissue loss, one patient with an anterior wall necrosis due to descending cervical mediastinitis and three patients with extra-long tracheoesophageal fistulas (TEFs) (greater than 4.5 cm or >30% of the total tracheal length). In the case of the direct repair of a TEF with a proximal tracheal stenosis, the sternocleidomastoid muscle was used to reconstruct the tissue deficit caused by extensive loss of substance in the left lateral side of the tracheal wall. In case of repair through exclusion of the TEF, the sternocleidomastoid muscle was interposed between the visceral sutures after exclusion of the TEF by an endomechanical device, in one case even substituting the membranous part of the tracheal wall. Our technique allows rotation on the sternal head of the sternocleidomastoid muscle with the lowest rotation radius, pedicled to the sternal origin, detached from the mastoid process and superior nuchal line, thus providing optimal vascularization from the superior thyroid artery/external carotid artery and accessory vasculature from the suprascapular artery. Patients exhibited uneventful postoperative recovery concerning airway and digestive patency. The mean postoperative hospitalization duration was 41 days. The follow-up assessments were negative for postoperative complications. Conclusions: The use of sternocleidomastoid muscle flap was proposed to ensure repair and protection of the suture margin or to constitute a portion, as a scaffold, of the wall by leveraging the muscle’s vascularization and thickness. This technique may be considered a leading component in managing complex situations in tracheal surgery. Full article

(This article belongs to the Special Issue Recent Advances in Modern Thoracic Surgery)

► Show Figures

Figure 1

8 pages, 1995 KiB

Open AccessArticle

Left Ventricular Strains and Right Ventricular Longitudinal Shortening Are Associated in Healthy Adults—A Detailed Analysis from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Healthy Study

by Attila Nemes, Árpád Kormányos, Nóra Ambrus and Csaba Lengyel

Life 2024, 14(11), 1422; https://doi.org/10.3390/life14111422 - 4 Nov 2024

Introduction: The right ventricle (RV) lies on the left ventricle (LV), and their shapes and movements are characteristic and significantly different. The aim of the present study was to investigate the relationship between three-dimensional speckle-tracking echocardiography (3DSTE)-derived LV strains, which represent LV contractility [...] Read more.

Introduction: The right ventricle (RV) lies on the left ventricle (LV), and their shapes and movements are characteristic and significantly different. The aim of the present study was to investigate the relationship between three-dimensional speckle-tracking echocardiography (3DSTE)-derived LV strains, which represent LV contractility as quantitative features, and tricuspid annular plane systolic excursion (TAPSE) as determined by M-mode echocardiography, which represents the longitudinal movement of the RV, in healthy adults. Methods: A total of 79 healthy adults (mean age: 28.1 ± 6.3 years; 33 men) were enrolled in the present study. After two-dimensional Doppler echocardiography, 3DSTE-derived data acquisition was carried out in all cases, and detailed 3DSTE-based analysis was performed offline at a later date. Results: Reduced TAPSE was associated with increased global and basal LV radial strain (RS). Increased TAPSE was also associated not only with increased global and basal LV-RS but also with global LV longitudinal strain (LS). An increase in global LV-RS and global LV circumferential strain (CS) showed associations with other strains except for global LV-LS. An increase in global LV-LS did not show associations with other strains. Increased global LV-RS was associated with reduced TAPSE, while the degree of global LV-LS and global LV-CS did not show associations with TAPSE. Conclusions: Three-dimensional speckle-tracking echocardiography-derived LV-RS and LV-LS are associated with the longitudinal shortening of the RV represented by TAPSE in healthy adults. Full article

(This article belongs to the Special Issue Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—2nd Edition)

► Show Figures

Figure 1

10 pages, 834 KiB

Open AccessArticle

Optimal Timing of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Early Predictors of Neurological Outcomes in Postcardiac Arrest Patients

by Dongju Kim, Hanna Park, Sang-Min Kim and Won Young Kim

Life 2024, 14(11), 1421; https://doi.org/10.3390/life14111421 - 4 Nov 2024

The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recognized as predictors of various critical illnesses. Our study aimed to investigate whether the NLR and PLR measured at different timepoints could predict poor neurological outcomes at 6 months. This observational retrospective cohort [...] Read more.

The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recognized as predictors of various critical illnesses. Our study aimed to investigate whether the NLR and PLR measured at different timepoints could predict poor neurological outcomes at 6 months. This observational retrospective cohort study included adults who had experienced out-of-hospital cardiac arrest (OHCA) and received targeted temperature management between November 2015 and December 2020. Patients with an active infection, as confirmed by an initial blood culture, were excluded. Multivariate logistic regression models were used to determine the association between the NLR and PLR at 0, 24, and 48 h after return of spontaneous circulation and poor neurological outcomes, defined as a Cerebral Performance Category score of ≥3 at 6 months. The NLR at 24 h, but not the NLR or PLR at other timepoints, was significantly associated with poor neurological outcomes (odds ratio: 1.05; 95% CI: 1.01–1.09; p = 0.018). The NLR at 24 h showed moderate accuracy in predicting poor neurological outcomes, with an AUC of 0.619. A cutoff value of 9.0 achieved 72.5% sensitivity and 47.7% specificity. The NLR measured at 24 h after ROCS could be used for early neuroprognostication given its low cost and widespread availability. Full article

(This article belongs to the Special Issue Clinical Update for Resuscitation Science)

► Show Figures

Figure 1

15 pages, 516 KiB

Open AccessArticle

The Impact of COVID-19 on Migraine: The Patients’ Perspective

by Angelo Torrente, Paolo Alonge, Roberta Baschi, Laura Pilati, Vincenzo Di Stefano, Cecilia Camarda, Filippo Brighina and Roberto Monastero

Life 2024, 14(11), 1420; https://doi.org/10.3390/life14111420 - 4 Nov 2024

The COVID-19 pandemic represents a global health phenomenon that will sadly remain part of our history. It had innumerable consequences for society and people’s lives. With different mechanisms, COVID-19 has been pointed out as a factor in the pathophysiology of several secondary disorders [...] Read more.

The COVID-19 pandemic represents a global health phenomenon that will sadly remain part of our history. It had innumerable consequences for society and people’s lives. With different mechanisms, COVID-19 has been pointed out as a factor in the pathophysiology of several secondary disorders or the deterioration of pre-existing conditions. Migraine is a frequent disorder that can be influenced by several conditions, including psychologically stressful conditions or infectious diseases. The purpose of the present study is to gain insight into the influence of COVID-19 on the clinical characteristics of patients with migraine. A self-administrable questionnaire has been developed, asking for migraine features before and after COVID-19 infection. One hundred and two patients who had been infected at least once were included. After COVID-19 infection, 54 reported the worsening of migraine, 45 noticed no variation, and 3 reported an improvement. After the infection, 21 patients changed preventive therapy due to the loss of efficacy of the previous one. The most effective treatments in this subpopulation were gene-related peptide monoclonal antibodies. The presented data confirm that the influence of COVID-19 is heterogeneous in patients with migraine, but new treatments may be effective in controlling the symptoms among those who report a worsening of the disease. Full article

(This article belongs to the Section Epidemiology)

► Show Figures

Figure 1

15 pages, 1819 KiB

Open AccessArticle

What We Know So Far About ECG for Pancreatic Pseudocysts

by Paulina Kluszczyk, Beata Jabłońska, Michał Serafin, Aleksandra Tobiasz, Tomasz Kowalczyk, Sebastian Maślanka, Mateusz Chapuła, Piotr Wosiewicz and Sławomir Mrowiec

Life 2024, 14(11), 1419; https://doi.org/10.3390/life14111419 - 4 Nov 2024

Background: Endoscopic cysto-gastrostomy (ECG) has become the treatment of choice for pancreatic pseudocysts (PPCs). Endoscopic drainage of PPCs requires the creation of an anastomosis between the lumen of the PPCs and the lumen of the gastrointestinal tract. Various types of stents are used [...] Read more.

Background: Endoscopic cysto-gastrostomy (ECG) has become the treatment of choice for pancreatic pseudocysts (PPCs). Endoscopic drainage of PPCs requires the creation of an anastomosis between the lumen of the PPCs and the lumen of the gastrointestinal tract. Various types of stents are used for this purpose. The aim of the study is to compare the indications, quantity, and results of using double pigtail plastic stents (DPPSs) and lumen-apposing fully covered metal stents (LAMSs) in ECG. Methods: A retrospective analysis was conducted of 39 patients (24 men, 15 women) treated for PPCs in the Department of Digestive Tract Surgery and the Department of Gastroenterology and Hepatology between October 2018 and February 2023. The mean age of patients was 51.13 (28–77). Data about etiology, cyst diameter, type, and complications of the stents were collected. Results: DPPSs were placed in smaller cysts (108 vs. 140 millimeters, p = 0.04) and were maintained for a longer duration compared to LAMSs (106 vs. 34 days, p = 0.001). Cyst recurrence was reported less frequently in patients with a LAMS (0 (0%) vs. 4 (19.05%), p = 0.05) and the therapeutic success was non-significantly higher in the LAMS group compared to the DPPS group (100% vs. 85.71%), p = 0.095. Conclusions: Both DPPSs and LAMSs are characterized by high therapeutic success and low complication rates in patients undergoing ECG for PPCs. Full article

(This article belongs to the Special Issue Advances in Endoscopic, Surgical, and Interventional Radiological Management of Gastrointestinal Diseases)

► Show Figures

Figure 1

16 pages, 1776 KiB

Open AccessArticle

AI-Based Analysis of Ziehl–Neelsen-Stained Sputum Smears for Mycobacterium tuberculosis as a Screening Method for Active Tuberculosis

by Arief Budi Witarto, Bogdan Ceachi, Cristiana Popp, Sabina Zurac, Ioana Cristina Daha, Flora Eka Sari, Nirawan Putranto, Satria Pratama, Benyamin P. Octavianus, Luciana Nichita, Julian Gerald Dcruz, Cristian Mogodici, Mirela Cioplea, Liana Sticlaru, Mihai Busca, Oana Stefan, Irina Tudor, Carmen Dumitru, Alexandra Vilaia, Alexandra Bastian, Gheorghita Jugulete, Gyula Laszlo Fekete and Petronel Mustatea Show full author list Hide full author list

Life 2024, 14(11), 1418; https://doi.org/10.3390/life14111418 - 3 Nov 2024

Tuberculosis is the primary cause of death due to infection in the world. Identification of Mycobacterium tuberculosis in sputum is a diagnostic test, which can be used in screening programs—especially in countries with a high incidence of tuberculosis—to identify and treat those persons [...] Read more.

Tuberculosis is the primary cause of death due to infection in the world. Identification of Mycobacterium tuberculosis in sputum is a diagnostic test, which can be used in screening programs—especially in countries with a high incidence of tuberculosis—to identify and treat those persons with the highest risk of disseminating the infection. We previously developed an algorithm which is able to automatically detect mycobacteria on tissue; in particular, our algorithm identified acid-fast bacilli on tissue with 100% specificity, 95.65% sensitivity, and 98.33% accuracy. We tested this algorithm on 1059 Ziehl–Neelsen-stained sputum smears to evaluate its results as a possible tool for screening. The results were displayed as a heat map of 32 × 32 pixel patches. Analysis of the positive patches revealed a good specificity (86.84%) and 100% sensitivity for patches with a level of confidence over 90; furthermore, the accuracy remained over 95% for all levels of confidence over 80, except the class (95–100]. The modest specificity is caused by the peculiarities of smears (uneven thickness, dust contamination, lack of coverslip). We will train the algorithm on sputum smears to increase the specificity to over 95%. However, as our algorithm showed no false negatives, it is suitable for screening. Full article

(This article belongs to the Section Microbiology)

► Show Figures

Figure 1

17 pages, 2670 KiB

Open AccessArticle

Development, Analysis, and Determination of Pharmacokinetic Properties of a Solid SMEDDS of Voriconazole for Enhanced Antifungal Therapy

by Hitesh Kumar Dewangan, Rajiv Sharma, Kamal Shah and Perwez Alam

Life 2024, 14(11), 1417; https://doi.org/10.3390/life14111417 - 2 Nov 2024

Background: Voriconazole is an antifungal drug, which is classified under Bio-Classification System-II and has low water solubility (0.71 mg/mL) and high permeability. Hardly any endeavors have been made to increase the bioavailability of voriconazole. Objective: To develop and evaluate a solid SMEDDS (self-microemulsifying [...] Read more.

Background: Voriconazole is an antifungal drug, which is classified under Bio-Classification System-II and has low water solubility (0.71 mg/mL) and high permeability. Hardly any endeavors have been made to increase the bioavailability of voriconazole. Objective: To develop and evaluate a solid SMEDDS (self-microemulsifying drug delivery system) for antifungal activity. Methods: Based on solubility studies of Labrafil-M 1994 CS (oil), Cremophor-RH 40 (a surfactant) and Transcutol-HP (a co-surfactant) were selected as components of the SMEDDS and a pseudo-ternary phase diagram was prepared. Thereafter, the oil, surfactant, and co-surfactant were mixed with altered weight ratios (1:1/1:2/2:1) and evaluated through various in vitro, in vivo analyses. Results: The particle size of the optimized formulation was observed to be 19.04 nm and the polydispersity index (PDI) value was found to be 0.162 with steady-state zeta potential. The optimized liquid SMEDDS was converted into a solid SMEDDS. Various adsorbents, such as Aerosil-200, Avicel-PH101, Neusilin-US2, and Neusilin UFL2 were screened to better detect the oil-absorbing capacity and flow properties of the powder. Neusilin UFL2 was selected as an adsorbent due to its better oil-absorbing capacity. DSC, X-ray diffraction, and dissolution studies were carried out to characterize the formulation. Further, the Pharmacokinetic profile was also studied in Wistar rats and the Cmax, tmax, and AUC0®t were calculated. The Cmax and AUC0®t plasma concentration is considerably better for the SMEDDS than for the pure drug and marketed formulation. Conclusions: This investigation clearly reveals the potential of developing a solid SMEDDS for candidiasis and invasive aspergillosis treatment, with better efficacy as compared to the commercially available marketed formulation. Full article

(This article belongs to the Special Issue Revolutionizing Drug Delivery: Innovations in Targeted Therapeutic Nanocarriers)

13 pages, 2187 KiB

Open AccessArticle

Defense Mechanisms of Xylopia aromatica (Lam.) Mart. in the Dry Season in the Brazilian Savanna

by Felipe Campos, Maria Vieira, Marília Sousa, Letícia Jorge, Gisela Ferreira, Marcia Marques and Carmen Boaro

Life 2024, 14(11), 1416; https://doi.org/10.3390/life14111416 - 2 Nov 2024

Water availability and light during the dry and rainy seasons in the Cerrado may influence plants’ stomatal movement and the entry of CO₂ for organic synthesis, which is the main electron drain. A lower stomatal conductance may contribute to the energy accumulated [...] Read more.

Water availability and light during the dry and rainy seasons in the Cerrado may influence plants’ stomatal movement and the entry of CO₂ for organic synthesis, which is the main electron drain. A lower stomatal conductance may contribute to the energy accumulated in the chloroplasts being directed towards the synthesis of compounds, which contributes to the activity of antioxidant enzymes to neutralize reactive oxygen species. Xylopia aromatica is a characteristic Cerrado species, and it is often recommended for recovering degraded areas. This study aimed to investigate the influence of the dry and rainy seasons on the metabolic adjustments of Xylopia aromatica in a portion of the Brazilian savanna in the state of São Paulo. In the rainy season, better photosynthetic performance led to greater investment in essential oil production. In the dry season, the plants may direct part of their reducing sugars to the syntheses of carotenoids and anthocyanins, which may help the antioxidant enzymes to neutralize reactive oxygen species. Carotenoids assist in the dissipation of photosystem energy, which has the potential to cause oxidative stress. During this season, lower stomatal conductance prevented excessive water loss. These results suggest the acclimatization of this species to the conditions of the Brazilian savanna. Full article

(This article belongs to the Special Issue Elements Cycling and Plants’ Physiological Characteristics: A Soil–Plant–Atmosphere Continuum Perspective)

► Show Figures

Figure 1

12 pages, 1175 KiB

Open AccessArticle

Early Elevated Inflammatory Markers in SARS-CoV-2 Vaccinated Patients Are Associated with Reduced Mortality, Morbidity, and Lung Injury

by Osama Khayat, Maamoun Basheer, Mayss Derawy and Nimer Assy

Life 2024, 14(11), 1415; https://doi.org/10.3390/life14111415 - 2 Nov 2024

Background The development of vaccines against SARS-CoV-2 has proved to be a highly successful strategy. In this work, the aim is to study the effects of the SARS-CoV-2 vaccine on the production of inflammatory markers and how this affect morbidity and mortality. Electronic [...] Read more.

Background The development of vaccines against SARS-CoV-2 has proved to be a highly successful strategy. In this work, the aim is to study the effects of the SARS-CoV-2 vaccine on the production of inflammatory markers and how this affect morbidity and mortality. Electronic medical record (EMR) data from 210 patients diagnosed with COVID-19 from November 2020 to June 2021 were collected. The admitted patients were divided into three groups, the one-dose vaccinated, two-dose vaccinated, and the non-vaccinated. All patients were moderate or severe in disease level as defined by the WHO classification. The results show that CRP was 101 ± 5.3, 97 ± 10.8, and 145 ± 17.3 (p < 0.05), fibrinogen 529 ± 16.3, 397 ± 33.8, and 610 ± 15 (p < 0.05), D-dimer 1244 ± 89, 1279 ± 297, and 1615 ± 224 (p < 0.05), ferritin was 1170 ± 122, 999 ± 202, and 1663 ± 409 (p < 0.05), IL-6 was 196 ± 12, 96 ± 5, and 580 ± 402 (NS), for the non-vaccinated, one-dose vaccinated, and two-dose vaccinated groups, respectively. The high level of CRP up to 150–200 mg/dL was more common among the surviving vaccinated patients. Oxygen supplementation, mechanical ventilation, and mortality were higher in the non-vaccinated group. Blood urea nitrogen (BUN) level was higher in the vaccinated patients, 25 ± 0.14 vs. 33 ± 6.15, respectively (p < 0.05). Inflammation markers were significantly higher in the vaccinated groups compared to non-vaccinated groups. On the other hand, extremely high levels of CRP (>200 mg/dL) were correlated with high mortality incidence. Full article

(This article belongs to the Section Physiology and Pathology)

► Show Figures

Figure 1

18 pages, 3048 KiB

Open AccessArticle

The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats

by Andreea Clim, Minela Aida Maranduca, Nina Filip, Daniela Maria Tănase, Mariana Floria, Alin Constantin Pinzariu, Irene Paula Popa, Roxana Nemteanu, Tudor Cristian Cozma, Flaviu Ionut Faur, Dragomir Nicolae Serban, Dragoș Viorel Scripcariu and Ionela Lacramioara Serban

Life 2024, 14(11), 1414; https://doi.org/10.3390/life14111414 - 2 Nov 2024

Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months, 450–550 [...] Read more.

Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months, 450–550 g, were allocated into three groups. From the beginning of the study, the first group (G-I, control) received only standard food, while the second and third groups (G II—obese, G III—diabetic) were administered a high-fat diet (HFD) with 2% cholesterol. After 2 weeks of accommodation, the specimens in G-III were injected intraperitoneal (i.p.) streptozotocin (35 mg of body weight, pH 4.5), intervention followed by the onset of type 2 diabetes mellitus. Following confirmation of diabetes onset, the specimens in G III were administered concomitantly with the HFD a daily gavage of atorvastatin 20 mg of body weight/day for 20 days. We measured, at the beginning and the end of the study, the Hcy levels, lipid profile, vitamin B12, B6, folic acid, and various parameters of oxidative stress (OS)—total antioxidant status (TAS), glutathione peroxidase (GPX) and superoxide dismutase (SOD). Results: After treatment with atorvastatin, the lipid profile in G III significantly improved compared to the other two groups, but enzymatic markers of oxidative stress did not closely parallel this trend. However, after the treatment of statin, we observed an important reduction in Hcy values. Conclusion: Our results demonstrate that treatment with atorvastatin can be used not only for its lipid-lowering properties and antioxidant effects but also to reduce Hcy concentration in this experimental model of diabetic rats. Moreover, atorvastatin therapy improves lipid profiles, reduces inflammation, suppresses oxidation, and decreases Hcy levels, potentially preventing major adverse cardiovascular events. Full article

(This article belongs to the Special Issue Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges)

► Show Figures

Figure 1

11 pages, 1730 KiB

Open AccessCase Report

Nitroglycerin (NTG) Infusion for Intraprocedural Vasospasm in Transarterial Microembolization (TAME): A Case Series

by Kuan-Wei Li, Keng-Wei Liang, Wen-Ying Liao, Chien-Kuo Wang, Yi-Sheng Liu, Tai-Hua Yang, Chun-Hsin Wu and Bow Wang

Life 2024, 14(11), 1413; https://doi.org/10.3390/life14111413 - 1 Nov 2024

Transarterial microembolization (TAME) is an innovative approach to treating chronic musculoskeletal pain. During the procedure, intraprocedural vasospasm, presenting juxta-catheter stenosis, and poor distal artery perfusion and flow through the anastomosis commonly pose challenges. Difficulty of the catheter reaching the target vessel and restricted [...] Read more.

Transarterial microembolization (TAME) is an innovative approach to treating chronic musculoskeletal pain. During the procedure, intraprocedural vasospasm, presenting juxta-catheter stenosis, and poor distal artery perfusion and flow through the anastomosis commonly pose challenges. Difficulty of the catheter reaching the target vessel and restricted drug delivery are possible consequences. To address these issues, transcatheter nitroglycerin (NTG) infusion at the extremity’s small-sized artery has been introduced. We investigated patients who underwent the TAME procedure wherein NTG was employed and sourced from two institutional settings. Transcatheter NTG infusion was administered in seven instances of chronic musculoskeletal pain manifesting with intraprocedural vasospasm during TAME procedures. Patient profiles, preprocedural imaging, fluoroscopic findings, adverse events, and Numerical Rating Scale (NRS) scores were evaluated. As a result, all seven cases experiencing intraprocedural vasospasm exhibited rapid responses to transcatheter NTG infusion. Angiography conducted pre- and post-infusion demonstrated increased vessel size, resolved proximal catheter stenosis, and improved distal perfusion. One case presented an adverse effect of self-limited transient hypotension. The NRS scores decreased following the procedure. Transcatheter NTG infusion at the extremity’s small-sized muscular artery can be an effective technique for resolving intraprocedural vasospasm in TAME procedures, irrespective of the target diseases and approach vessels. Full article

(This article belongs to the Special Issue A Paradigm Shift in Airway and Pain Management—2nd Edition)

► Show Figures

Figure 1

12 pages, 1714 KiB

Open AccessArticle

A Novel Solid Media-Free In-Planta Soybean (Glycine max. (L) Merr.) Transformation Approach

by Muhammad Waqar Khan, Aaqib Shaheen, Xuebin Zhang, Yaser Hassan Dewir and Nóra Mendler-Drienyovszki

Life 2024, 14(11), 1412; https://doi.org/10.3390/life14111412 - 1 Nov 2024

Soybean’s lengthy protocols for transgenic plant production are a bottleneck in the transgenic breeding of this crop. Explants cultured on a medium for an extended duration exhibit unanticipated modifications. Stress-induced somaclonal variations and in vitro contaminations also cause substantial losses of transgenic plants. [...] Read more.

Soybean’s lengthy protocols for transgenic plant production are a bottleneck in the transgenic breeding of this crop. Explants cultured on a medium for an extended duration exhibit unanticipated modifications. Stress-induced somaclonal variations and in vitro contaminations also cause substantial losses of transgenic plants. This effect could potentially be mitigated by direct shoot regeneration without solid media or in-planta transformation. The current study focused primarily on developing a rapid and effective media-free in-planta transformation technique for three soybean genotypes (Wm82) and our newly developed two hybrids, designated as ZX-16 and ZX-3. The whole procedure for a transgenic plant takes the same time as a stable grown seedling. Multiple axillary shoots were regenerated on stable-grown soybean seedlings without the ectopic expression of developmental regulatory genes. An approximate amount of 200 µL medium with a growth regulator was employed for shoot organogenesis and growth. The maximal shoot regeneration percentages in the Wm82 and ZX-3 genotypes were 87.1% and 84.5%, respectively. The stable transformation ranged from 3% to 8.0%, with an average of 5.5%. This approach seems to be the opposite of the hairy root transformation method, which allowed transgenic shoots to be regenerated on normal roots. Further improvement regarding an increase in the transformation efficiency and of this technique for a broad range of soybean genotypes and other dicot species would be extremely beneficial in achieving increased stable transformation. Full article

(This article belongs to the Special Issue Effects of Environmental Factors on Challenges of Plant Breeding)

► Show Figures

Figure 1

20 pages, 5394 KiB

Open AccessArticle

Metagenomic Analysis of Sediment Bacterial Diversity and Composition in Natural Lakes and Artificial Waterpoints of Tabuk Region in King Salman Bin Abdulaziz Royal Natural Reserve, Saudi Arabia

by Yahya S. Al-Awthan, Rashid Mir, Basmah M. Alharbi, Abdulaziz S. Alatawi, Fahad M. Almutairi, Tamer Khafaga, Wael M. Shohdi, Amal M. Fakhry and Mashari M. Alatawi

Life 2024, 14(11), 1411; https://doi.org/10.3390/life14111411 - 1 Nov 2024

The Tabuk region is located in the northern part of Saudi Arabia, and it has an area of 117,000 km² between longitudes 26° N and 29° N and latitudes 34° E and 38° E. King Salman Bin Abdulaziz Royal Natural Reserve (KSRNR) [...] Read more.

The Tabuk region is located in the northern part of Saudi Arabia, and it has an area of 117,000 km² between longitudes 26° N and 29° N and latitudes 34° E and 38° E. King Salman Bin Abdulaziz Royal Natural Reserve (KSRNR) is the largest natural reserve in Saudi Arabia and covers about 130,700 km². It represents a new tourist attraction area in the Tabuk region. Human activities around the lake may lead to changes in water quality, with subsequent changes in microenvironment components, including microbial diversity. The current study was designed to assess possible changes in bacterial communities of the water sediment at some natural lakes and artificial waterpoints of KSRNR. Water samples were collected from ten different locations within KSRNR: W1, W2, W3 (at the border of the royal reserve); W4, W5, W6, W7 (at the middle); and W8, W9, and W10 (artificial waterpoints). The total DNA of the samples was extracted and subjected to 16S rRNA sequencing and metagenomic analysis; also, the environmental parameters (temperature and humidity) were recorded for all locations. Metagenomic sequencing yielded a total of 24,696 operational taxonomic units (OTUs), which were subsequently annotated to 193 phyla, 215 classes, 445 orders, 947 families, and 3960 genera. At the phylum level, Pseudomonadota dominated the microbial communities across all samples. At the class level, Gammaproteobacteria, Clostridia, Alphaproteobacteria, Bacilli, and Betaproteobacteria were the most prevalent. The dominant families included Enterobacteriaceae, Pseudomonadaceae, Clostridiaceae, Comamonadaceae, and Moraxellaceae. At the genus level, Pseudomonas, Clostridium, Acinetobacter, Paenibacillus, and Acidovorax exhibited the highest relative abundances. The most abundant species were Hungatella xylanolytica, Pseudescherichia vulneris, Pseudorhizobium tarimense, Paenibacillus sp. Yn15, and Enterobacter sp. Sa187. The observed species richness revealed substantial heterogeneity across samples using species richness estimators, Chao1 and ACE, indicating particularly high diversity in samples W3, W5, and W6. Current study results help in recognizing the structure of bacterial communities at the Tubaiq area in relation to their surroundings for planning for environmental protection and future restoration of affected ecosystems. The findings highlight the dominance of various bacterial phyla, classes, families, and genera, with remarkable species richness in some areas. These results underscore the influence of human activities on microbial diversity, as well as the significance of monitoring and conserving the reserve’s natural ecosystems. Full article

(This article belongs to the Section Microbiology)

► Show Figures

Figure 1

12 pages, 2658 KiB

Open AccessArticle

Positive Outcomes of Supplementation with Lecithin-Based Delivery Formulation of Curcuma longa and Boswellia serrata in IBS Subjects with Small Bowel Dysbiosis

by Attilio Giacosa, Gaetan Claude Barrile, Simone Perna and Mariangela Rondanelli

Life 2024, 14(11), 1410; https://doi.org/10.3390/life14111410 - 1 Nov 2024

Background: Small bowel dysbiosis (SBD) is a frequent finding in subjects with irritable bowel syndrome (IBS). The sunflower lecithin (phytosome) formulation of Curcuma longa and Boswellia serrata demonstrated beneficial effects on intestinal microbiota. This study aimed to evaluate the impact of a lecithin-based [...] Read more.

Background: Small bowel dysbiosis (SBD) is a frequent finding in subjects with irritable bowel syndrome (IBS). The sunflower lecithin (phytosome) formulation of Curcuma longa and Boswellia serrata demonstrated beneficial effects on intestinal microbiota. This study aimed to evaluate the impact of a lecithin-based delivery formulation of Curcuma longa and Boswellia serrata extracts (CUBO) on SBD in IBS subjects. Subjects: Forty-nine adult subjects with IBS and SBD were randomly supplemented for 30 days with CUBO and a low-FODMAP diet (LFD) (intervention) or with LFD and placebo (control group). Results: The intervention group showed a significant reduction in urinary indican (p < 0.001), which was the marker of SBD, and of abdominal bloating (p < 0.001) and abdominal pain (p < 0.001). The pre–post control group analysis did not evidence significant differences. The comparison between the two groups (net effect in intervention minus control subjects) showed that the changes differ significantly for urinary indican p < 0.001 (−42.88; 95% CI: −62.04 to −23.72), abdominal bloating p < 0.001 (−1.50; 95% CI: −1.93 to −1.07), and abdominal pain p < 0.001 (−2.37; 95% CI: −3.61 to −1.13) and for the global assessment of efficacy (p < 0.001). The efficacy was 20% greater in males than in females. Conclusions: In IBS subjects, the intervention with CUBO and LFD shows a significantly higher reduction in SBD, abdominal pain, and bloating compared to LFD and placebo. Additional research is needed to confirm these data. Full article

(This article belongs to the Section Pharmaceutical Science)

► Show Figures

Figure 1

13 pages, 5260 KiB

Open AccessArticle

Astaxanthin Protects Against H₂O₂- and Doxorubicin-Induced Cardiotoxicity in H9c2 Rat Myocardial Cells

by Roman Krestinin, Margarita Kobyakova, Yulia Baburina, Linda Sotnikova and Olga Krestinina

Life 2024, 14(11), 1409; https://doi.org/10.3390/life14111409 - 1 Nov 2024

Astaxanthin (AST) is a carotenoid that has positive effects on various organs and tissues. It also exhibits a cardioprotective action. In this study, the influence of AST on the survival of H9c2 cardiomyocytes under hydrogen peroxide (H₂O₂)- and doxorubicin [...] Read more.

Astaxanthin (AST) is a carotenoid that has positive effects on various organs and tissues. It also exhibits a cardioprotective action. In this study, the influence of AST on the survival of H9c2 cardiomyocytes under hydrogen peroxide (H₂O₂)- and doxorubicin (DOX)-induced cardiotoxicity was investigated. Under these conditions, the content of cytosolic Ca²⁺ was measured, and changes in the area of the mitochondrial mass, as well as in the content of the voltage-dependent anion channel 1 (VDAC1), the autophagy marker LC3A/B, and the pro-apoptotic transcription factor homologous protein (CHOP), were determined. It was found that AST removed the cytotoxic effect of H₂O₂ and DOX, while cell survival increased, and the mitochondrial mass did not differ from the control. At the same time, a decrease in the content of cytosolic Ca²⁺ and the restoration of the VDAC1 level to values close to the control were observed. The restoration of the CHOP level suggests a reduction in endoplasmic reticulum (ER) stress in cells. The results allow us to consider AST as a potential agent in the prevention and/or treatment of cardiac diseases associated with oxidative stress. Full article

(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application–2nd Edition)

► Show Figures

Figure 1

16 pages, 1458 KiB

Open AccessArticle

Genetic Insights on Meropenem Resistance Concerning Klebsiella pneumoniae Clinical Isolates

by Fathy M. Elkady, Bahaa M. Badr, Abdel-Aty E. Alfeky, Mohammed S. Abdulrahman, Amr H. Hashem, Abdulaziz A. Al-Askar, Gehad AbdElgayed and Hany R. Hashem

Life 2024, 14(11), 1408; https://doi.org/10.3390/life14111408 - 1 Nov 2024

The transferable genetic elements are associated with the dissemination of virulence determinants amongst Klebsiella pneumoniae. Thus, we assessed the correlated antimicrobial resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates. Each isolate’s ability to biosynthesize biofilm, carbapenemase, and extended-spectrum β-lactamase were examined. Genotypically, the [...] Read more.

The transferable genetic elements are associated with the dissemination of virulence determinants amongst Klebsiella pneumoniae. Thus, we assessed the correlated antimicrobial resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates. Each isolate’s ability to biosynthesize biofilm, carbapenemase, and extended-spectrum β-lactamase were examined. Genotypically, the biofilm-, outer membrane porin-, and some plasmid-correlated antimicrobial resistance genes were screened. About 50% of the isolates were multidrug-resistant while 98.4% were extended-spectrum β-lactamase producers and 89.3% were carbapenem-resistant. Unfortunately, 93.1% of the multidrug-resistant isolates produced different biofilm levels. Additionally, fimD and mrkD genes encoding adhesins were detected in 100% and 55.2% of the tested isolates, respectively. Also, the bla_KPC, bla_OXA-48-like, and bla_NDM-encoding carbapenemases were observed in 16.1%, 53.6%, and 55.4% of the tested isolates, respectively. Moreover, the bla_SHV and bla_CTX-M extended-spectrum β-lactamase-associated genes were detected at 95.2% and 61.3%, respectively. Furthermore, aac(3)IIa, qnrB, and tetB resistance-correlated genes were observed in 38.1%, 46%, and 7.9% of the tested isolates, respectively. Certainly, the tested antimicrobial resistance-encoding genes were concurrently observed in 3.2% of the tested isolates. These findings confirmed the elevated prevalence of various antimicrobial resistance-associated genes in Klebsiella pneumoniae. The concurrent transferring of plasmid-encoding antimicrobial resistance-related genes could be associated with the possible acquisition of multidrug-resistant Klebsiella pneumoniae phenotypes. Full article

(This article belongs to the Special Issue Infection, Colonization, and Spread of Drug-Resistant Bacteria)

► Show Figures

Figure 1

25 pages, 5147 KiB

Open AccessArticle

Stochastic Processes Dominate the Assembly of Soil Bacterial Communities of Land Use Patterns in Lesser Khingan Mountains, Northeast China

by Junnan Ding and Shaopeng Yu

Life 2024, 14(11), 1407; https://doi.org/10.3390/life14111407 - 31 Oct 2024

To meet the demands of a growing population, natural wetlands are being converted to arable land, significantly impacting soil biodiversity. This study investigated the effects of land use changes on bacterial communities in wetland, arable land, and forest soils in the Lesser Khingan [...] Read more.

To meet the demands of a growing population, natural wetlands are being converted to arable land, significantly impacting soil biodiversity. This study investigated the effects of land use changes on bacterial communities in wetland, arable land, and forest soils in the Lesser Khingan Mountains using Illumina MiSeq 16S rRNA sequencing. Soil physicochemical properties and enzyme activities were measured using standard methods, while microbial diversity was assessed through sequencing analysis. Our findings revealed that forest soils had significantly higher levels of total potassium (2.62 g·kg⁻¹), electrical conductivity (8.22 mS·cm⁻¹), urease (0.18 mg·g⁻¹·d⁻¹), and nitrate reductase (0.13 mg·g⁻¹·d⁻¹), attributed to rich organic matter and active microbial communities. Conversely, arable soils showed lower total potassium (1.94 g·kg⁻¹), reduced electrical conductivity, and suppressed enzyme activities due to frequent tilling and fertilization. Wetland soils exhibited the lowest values primarily due to water saturation, which limits organic matter decomposition and microbial activity. Land use changes notably reduced microbial diversity, with conversion from forest to arable land leading to habitat loss. Forest soils supported higher abundances of Proteobacteria (37.59%) and Actinobacteriota (34.73%), while arable soils favored nitrogen-fixing bacteria. Wetlands were characterized by chemoheterotrophic and anaerobic bacteria. Overall, these findings underscore the profound influence of land use on soil microbial communities and their functional roles, highlighting the need for sustainable management practices. Full article

(This article belongs to the Special Issue Advances in the Structure and Function of Microbial Communities)

► Show Figures

Figure 1

More Articles...

Submit to Life Review for Life

Journal Menu

Journal Browser

► Journal Browser

Highly Accessed Articles

View More...

Latest Books

More Books and Reprints...

E-Mail Alert

News

5 November 2024
MDPI INSIGHTS: The CEO's Letter #17 - OA Week, Basel Open Day, Beijing Graphene Forum

4 November 2024
Meet Us at the 29th tRNA Conference, 18–22 November 2024, Kanazawa, Japan

1 November 2024
Meet Us at the 63rd Annual Meeting of Japanese Retina and Vitreous Society, 6–8 December 2024, Osaka, Japan

More News & Announcements...

Topics

Propose a Topic

Topic in Agronomy, Horticulturae, IJPB, Life, Plants

Effects of Climate Change on Viticulture (Grape) Topic Editors: Arif Atak, Andreia Figueiredo, Inmaculada Pascual, Fermin Morales
Deadline: 31 December 2024

Topic in Molecules, Biomimetics, Chemosensors, Life, AI, Sci

Recent Advances in Chemical Artificial Intelligence Topic Editors: Pier Luigi Gentili, Jerzy Górecki, David C Magri, Pasquale Stano
Deadline: 1 March 2025

Topic in Antioxidants, Foods, IJPB, Life, Molecules

New Insights of Natural Compounds in Antioxidant and Anti-Inflammatory Properties Topic Editors: Jung Eun Kim, Bo Young Chung
Deadline: 31 March 2025

Topic in Diversity, Geosciences, Life, Fossil Studies

Problems and Hypotheses in Palaeontology Topic Editors: Eric Buffetaut, Julien Claude
Deadline: 15 April 2025

More Topics

Conferences

Announce Your Conference

31 March–2 April 2025 Join Us at the International Conference Plants 2025: From Seeds to Food Security, 31 March–2 April 2025, Barcelona, Spain

More Conferences...

Special Issues

Propose a Special Issue

Special Issue in Life

Obstetrics and Gynecology Medicine: Go From Bench to Bedside Guest Editors: Stefano Canosa, Anna Maria Nuzzo
Deadline: 8 November 2024

Special Issue in Life

Emerging Knowledge on Human Immunodeficiency Virus Guest Editors: Giota Lourida, Dimitrios Paraskevis
Deadline: 18 November 2024

Special Issue in Life

Focus on Exercise Physiology and Sports Performance Guest Editor: Laikang Yu
Deadline: 19 November 2024

Special Issue in Life

Obstructive Sleep Apnea: Current Knowledge and Future Perspectives Guest Editors: Doina Todea, Larry D. Sanford
Deadline: 21 November 2024

More Special Issues

Topical Collections

Topical Collection in Life

Heart Failure and Heart Transplantation Collection Editors: Rasmus Rivinius, Andreas Doesch, Daniel Oehler

Topical Collection in Life

Tumor Progression, Microenvironments, and Therapeutics Collection Editors: Hung-Chi Cheng, Chun-Li Su, Ming-Fen Lee

Topical Collection in Life

The Role of Bioactive Natural Compounds in the Treatment of Diseases Collection Editor: Stefania Lamponi

Topical Collection in Life

State of the Art in Plant Science Collection Editors: Kousuke Hanada, Yoshiteru Noutoshi

More Topical Collections

Back to TopTop