South San Francisco, California, United States
Contact Info
1K followers
500+ connections
South San Francisco, California, United States
Contact Info
1K followers
500+ connections
About
Experienced drug hunter.
Large molecule drug discovery including monoclonal antibody…
Large molecule drug discovery including monoclonal antibody…
Activity
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Resharing this interesting analysis on the financial impact of a PhD in the biotech/pharma space. 👇 As someone who has transitioned from academia…
Resharing this interesting analysis on the financial impact of a PhD in the biotech/pharma space. 👇 As someone who has transitioned from academia…
Liked by Xiaoshan Min
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We are looking for a leader in CADD & ML/AI to join us in our mission to deliver for patients!! Btw, our cryoEM facility just came online and our…
We are looking for a leader in CADD & ML/AI to join us in our mission to deliver for patients!! Btw, our cryoEM facility just came online and our…
Liked by Xiaoshan Min
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Antibody therapies are at the forefront of multimodal drug discovery, and sophisticated antibody engineering is essential to this process. Software…
Antibody therapies are at the forefront of multimodal drug discovery, and sophisticated antibody engineering is essential to this process. Software…
Liked by Xiaoshan Min
Experience & Education
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RemeGen Biosciences
View Xiaoshan’s full experience
See their title, tenure and more.
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Publications
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Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
Communications Biology
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Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile
Bioorganic & Medicinal Chemistry Letters
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Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Science Advances
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Mechanistic Studies of Cytochrome P450 3A4 Time Dependent Inhibition Using Two Cysteine- Targeting Electrophiles.
Drug Metab Dispos
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Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists
ACS Med Chem Lett
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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Science Translational Medicine
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An inhibitory antibody against dipeptidyl peptidase IV improves glucose tolerance in vivo
J.Biol.Chem.
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Molecular basis of sphingosine kinase 1 substrate recognition and catalysis
Structure
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Structure guided design of a series of sphingosine kinase (SphK) inhibitors
Bioorg Med Chem Lett
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Crystal structure of a single-chain trimer of human adiponectin globular domain
FEBS lett.
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Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation
J.Biol.Chem.
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Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)
PNAS
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Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors
Bioorg Med Chem Lett
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Generation of novel long-acting globular adiponectin molecules.
J.Mol.Biol.
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Structural studies of MAP Kinase cascade components
Methods Mol Biol.
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The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution
Structure
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The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Structure
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Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Chem Biol Drug Des.
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Substrate and docking interactions in serine/threonine protein kinases
Chemical Review
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Properties of WNK1 and implications for other family members
J.Biol.Chemistry
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WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension
Cell Research
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Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
Structure
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Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry.
Molecular Cell
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WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding
Molecular Cell
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Regulation of WNK1 by an autoinhibitory domain and autophosphorylation
J.Biol.Chemistry
Patents
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Growth differentiation factor 15 (GDF-15) constructs
US US9862752B2
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Growth differentiation factor 15 (GDF-15) polypeptides
US US10336798B2
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Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
US 16/623,750, 2021
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ST2 antigen binding proteins
US US9382318B2
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TIGIT AND CD112R BLOCKADE
US 17/375,958
More activity by Xiaoshan
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Today in @ScienceMagazine, together with my former colleagues at the Novartis Institutes for BioMedical Research, we report the discovery and…
Today in @ScienceMagazine, together with my former colleagues at the Novartis Institutes for BioMedical Research, we report the discovery and…
Liked by Xiaoshan Min
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Check out a new perspective article on phage display technology and its impact in the discovery of novel protein-based drugs, written by my long-time…
Check out a new perspective article on phage display technology and its impact in the discovery of novel protein-based drugs, written by my long-time…
Liked by Xiaoshan Min
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I am so thankful to have taken part in the NSF NSDA RStudio workshop this week. With the vast amounts of data available to scientists today…
I am so thankful to have taken part in the NSF NSDA RStudio workshop this week. With the vast amounts of data available to scientists today…
Liked by Xiaoshan Min
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Consider exploring the Polyvalan Xo4 nucleating agent at various concentrations to optimize your research since it's highly protein-dependent. If the…
Consider exploring the Polyvalan Xo4 nucleating agent at various concentrations to optimize your research since it's highly protein-dependent. If the…
Liked by Xiaoshan Min
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A commitment to quality is essential to bringing your innovative therapy to market. Learn how to identify a quality CDMO in our new whitepaper.
A commitment to quality is essential to bringing your innovative therapy to market. Learn how to identify a quality CDMO in our new whitepaper.
Liked by Xiaoshan Min
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