The definition of a spreadsheet is a piece of paper or a computer program used for accounting and recording data using rows and columns into which information can be entered. Microsoft Excel, a program in which you enter data into columns, is an example of a spreadsheet programThe definition of a spreadsheet is a piece of paper or a computer program used for accounting and recording data using rows and columns into which information can be entered. Microsoft Excel, a program in which you enter data into columns, is an example of a spreadsheet program