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History
- June 20, 2018.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Fan Zhang1,2,3,4,5,^,
- Kevin Wei5,^,
- Kamil Slowikowski1,2,3,4,5,^,
- Chamith Y. Fonseka1,2,3,4,5,^,
- Deepak A. Rao5,^,
- Stephen Kelly6,
- Susan M. Goodman7,8,
- Darren Tabechian9,
- Laura B. Hughes10,
- Karen Salomon-Escoto11,
- Gerald F. M. Watts5,
- William Apruzzese5,
- David J. Lieb4,
- David L. Boyle12,
- Arthur M. Mandelin II13,
- Accelerating Medicines Partnership: RA Phase 1, AMP RA/SLE14,
- Brendan F. Boyce15,
- Edward DiCarlo8,16,
- Ellen M. Gravallese11,
- Peter K. Gregersen17,
- Larry Moreland18,
- Gary S. Firestein12,
- Nir Hacohen4,
- Chad Nusbaum4,
- James A. Lederer19,
- Harris Perlman13,
- Costantino Pitzalis20,
- Andrew Filer21,22,
- V. Michael Holers23,
- Vivian P. Bykerk1,
- Laura T. Donlin8,24,*,
- Jennifer H. Anolik9,25,*,
- Michael B. Brenner5,* and
- Soumya Raychaudhuri1,2,3,4,5,26,*
- 1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA
- 2Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
- 3Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA
- 4Broad Institute of Massachusetts Institute and Technology and Harvard University, Cambridge, MA 02142, USA
- 5Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, MA 02115, USA
- 6Department of Rheumatology, Barts Health NHS Trust, London, E1 1BB, UK
- 7Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
- 8Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
- 9Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
- 10Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA
- 11Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
- 12Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093 USA
- 13Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine. Chicago, IL 60611, USA
- 14AMP RA Phase 1: full list of members and affiliations appears in the end of the paper
- 15Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
- 16Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA
- 17Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY 11030, USA
- 18Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 USA
- 19Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, MA 02115, USA
- 20Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, E1 4NS, UK
- 21Rheumatology Research Group, Institute of Inflammation and Ageing, The University of Birmingham, Birmingham, B15 2WB, UK
- 22University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK
- 23Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80220, USA
- 24Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY 10021, USA
- 25Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
- 26Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
- 27Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
- 28Department of Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
- 29Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
- 30David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
- 31Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
- 32The Rockefeller University, New York, NY 10065, USA
- 33Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA
- 34The Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, CA 94305, USA
- Correspondence and requests for materials should be addressed to, Soumya Raychaudhuri, 77 Avenue Louis Pasteur, Harvard New Research Building, Suite 250D, Boston, MA 02446, USA. soumya{at}broadinstitute.org; 617-525-4484 (tel); 617-525-4488 (fax)
Posted June 20, 2018.
Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry
