Genome Biology is calling for submissions to our Collection on key genetic determinants and functional consequences of genome editing interventions in the context of cancer.
Understanding the molecular pathways essential for cancer progression is of paramount importance in advancing both basic research and clinical applications. By employing CRISPR/Cas9 and related methods for targeted genome editing and high-throughput screens, researchers can systematically dissect the genetic determinants of cancer, identify novel therapeutic targets, and enhance our comprehension of the regulatory networks orchestrating oncogenic processes. This brings insights into the functional consequences of genetic alterations, paving the way for the development of personalized and effective cancer treatments.
Through a genome-wide exploration using CRISPR and other editing tools, the Collection aims to offer unprecedented insights into the functional genomic landscape of cancer. It provides a platform for cutting-edge research at the intersection of genome editing technology and cancer biology to advance our understanding of cancer progression by elucidating molecular pathways, identifying key genetic determinants, and exploring the functional consequences of genome editing interventions. Topics of interest include but are not limited to, the following:
- Functional genomics approaches and insights
- Exploration of tumor suppressor genes and oncogenes
- Immune modulation using CRISPR/Cas9 or other editing tools
- Combinatorial screens profiling genetic interactions and analytical tools designed for these screens
- Targeting the undruggable genome and exploration of novel drug targets
This Collection supports and amplifies research related to SDG 3: Good Health and Well-being.
Image credit: © vchalup / stock.adobe.com