The parents of Arizona's 10-year-old patient offer the hospital a generous donation, but Arizona finds herself in a conflict of interest when the patient's condition worsens; Cristina tests her boundaries with Owen.
Despite their chaotic personal lives, the women decide to follow through with the big dinner party the late Mary Alice had planned to host.
The Lyons go to Philadelphia, where they see what their lives could have been like if Lucious hadn't been successful, another woman causes tension between Hakeem and hip-hop star Tianna.
Lucious has to defend Empire's IPO launch after one of his artists is involved in a shooting, Cookie hears about Lucious' plans for a huge performance for Hakeem, but not Jamal, Bunkie's murder is investigated.
Cookie receives an anonymous gift she suspects may be a veiled threat from a person from her past, Lucious takes charge of Hakeem's video shoot.