The human vaginal microbial community

Vaneechoutte, Mario

doi:10.1016/j.resmic.2017.08.001

Cited by 56 publications

(57 citation statements)

References 117 publications

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“…The variation of activity and abundance of those bacteria would be important for regulating nutrient metabolisms in coral holobiont. Interestingly, a number of bacteria, which has been previously detected in human microbiome, e.g., Bifidobacterium longum, Bacteroides acidifaciens, Lactococcus piscium, Parabacteroides sp., Akkermansia muciniphila, Muribaculum intestinale, Alistipes finegoldii, Megasphaera sp., Dermabacter vaginalis, Gardnerella vaginalis, Atopobium vaginae and Granulicatella adiacens [52][53][54], were found in nearly all explored corals. The functions of these bacteria have been widely reported in humans, e.g., a regulatory role in colon walls, a defense barrier enhancer, an intestinal motility modulator, an antiinflammatory action modulator [55], but their function in the coral holobiont remains unclear.…”

Section: Major Members and Potential Roles Of Coral Microbiomementioning

confidence: 99%

Unraveling Heterogeneity of Coral Microbiome Assemblages in Tropical and Subtropical Corals in the South China Sea

et al. 2020

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Understanding the coral microbiome is critical for predicting the fidelity of coral symbiosis with growing surface seawater temperature (SST). However, how the coral microbiome will respond to increasing SST is still understudied. Here, we compared the coral microbiome assemblages among 73 samples across six typical South China Sea coral species in two thermal regimes. The results revealed that the composition of microbiome varied across both coral species and thermal regimes, except for Porites lutea. The tropical coral microbiome displayed stronger heterogeneity and had a more un-compacted ecological network than subtropical coral microbiome. The coral microbiome was more strongly determined by environmental factors than host specificity. γ-(32%) and α-proteobacteria (19%), Bacteroidetes (14%), Firmicutes (14%), Actinobacteria (6%) and Cyanobacteria (2%) dominated the coral microbiome. Additionally, bacteria inferred to play potential roles in host nutrients metabolism, several keystone bacteria detected in human and plant rhizospheric microbiome were retrieved in explored corals. This study not only disentangles how different host taxa and microbiome interact and how such an interaction is affected by thermal regimes, but also identifies previously unrecognized keystone bacteria in corals, and also infers the community structure of coral microbiome will be changed from a compacted to an un-compacted network under elevated SST.

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Section: Major Members and Potential Roles Of Coral Microbiomementioning

confidence: 99%

Unraveling Heterogeneity of Coral Microbiome Assemblages in Tropical and Subtropical Corals in the South China Sea

et al. 2020

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“…A shift from Lactobacillus species dominance of the vaginal niche towards increased bacterial diversity and enrichment of pathobionts is a signature of vaginal dysbiosis, which has been associated with a range of pathology states including increased risk of sexually transmitted infections (Borgdorff et al, 2014) and various poor pregnancy outcomes including miscarriage (Al-Memar et al, 2019), prelabour premature rupture of the foetal membranes (Brown et al, 2019;Brown et al, 2018) and preterm birth (Fettweis et al, 2019;Kindinger et al, 2017;Kindinger et al, 2016;Vaneechoutte, 2017).…”

Section: Discussionmentioning

confidence: 99%

Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

Bonnardel

Haslam

Dell

et al. 2020

Preprint

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Lectins, such as adhesins and toxins, are carbohydrate-binding proteins that recognise glycans of cells and their secretions. While mediation of microbe-microbe and microbe-host interactions by lectins has long been recognised in the lung and gut, little is known about those in the vagina, where such interactions are implicated in health and various disease states. These include sexually transmitted infections, cervical cancer and poor pregnancy outcomes such as preterm birth. In this study, the curated UniLectin3D database was used to establish a lectin classification based primarily on taxonomy and protein 3D structure. The resulting 109 lectin classes were characterised by specific Hidden Markov Model (HMM) profiles. Screening of microbial genomes in the UniProt and NCBI NR sequence databases resulted in identification of >100 000 predicted bacterial lectins available at unilectin.eu/bacteria. Screening of the complete genomes of 90 isolates from 21 vaginal bacterial species showed that the predicted lectomes (ensemble of predicted lectins) of Lactobacilli associated with vaginal health are substantially less diverse than those of pathogens and pathobionts. Both the number of predicted bacterial lectins, and their specificities for carbohydrates correlated with pathogenicity. This study provides new insights into potential mechanisms of commensal and pathogen colonisation of the reproductive tract that underpin health and disease states.

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“…Several studies have revealed that vaginal disorders and dysbiosis are closely related to lactobacillus decrease and pathogen increase (1). Lactobacillus crispatus is one of the dominant species in the normal vaginal environment and plays an important role in preventing infections such as bacterial vaginosis (BV) and in modulating inflammation (2). L. crispatus is a producer of lactic acid, hydrogen peroxide, and other antimicrobial compounds that inhibit the growth (3), hyphae, and biofilm formation of Candida albicans (4) and reduce the cytotoxicity of Gardnerella vaginalis (5) and the infectivity of Chlamydia trachomatis (6).…”

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confidence: 99%

“…L. crispatus is a producer of lactic acid, hydrogen peroxide, and other antimicrobial compounds that inhibit the growth (3), hyphae, and biofilm formation of Candida albicans (4) and reduce the cytotoxicity of Gardnerella vaginalis (5) and the infectivity of Chlamydia trachomatis (6). L. crispatus seems to possess additional protective mechanisms against BV and contributes to the maintenance of the normal vaginal microbiota (2).…”

mentioning

confidence: 99%

Draft Genome Sequence of Lactobacillus crispatus CIP 104459, Isolated from a Vaginal Swab

Clabaut

Boukerb

Racine

et al. 2020

Microbiol Resour Announc

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The human vaginal microbial community

Cited by 56 publications

References 117 publications

Unraveling Heterogeneity of Coral Microbiome Assemblages in Tropical and Subtropical Corals in the South China Sea

Unraveling Heterogeneity of Coral Microbiome Assemblages in Tropical and Subtropical Corals in the South China Sea

Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

Draft Genome Sequence of Lactobacillus crispatus CIP 104459, Isolated from a Vaginal Swab

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