Oxidative stress in psoriasis and potential therapeutic use of antioxidants

No abstract

Objective: to study the status of free-radical processes and antioxidant protection parameters in patients with psoriasis and concomitant essential hypertension.Materials and methods. Study of oxidative status was performed in 95 patients who were divided into 3 groups: I group -psoriasis and hypertension -25 people; II group -30 patients with psoriasis only and group III -40 patients with hypertension only. To assess the severity of skin lesions in psoriasis the index Psoriasis Area and Severity Index (PASI) were used. Protein oxidative destruction markersaldehydephenilhydrazones and ketophenylhydrazones -were determined under method of B. Halliwell.Results. Processes of carbonyl stress in the surveyed patients were studied taking into account the level of thiol-disulfi de balance. Both spontaneous and stimulated aldehyde phenylhydrazone were the lowest in patients with essential hypertension, in patients with psoriasis and essential hypertension the studied indicators were higher by 75.35 and 22.03 % (p<0.05) respectively, in patients with psoriasis -by 123.94 and 47.55 % (p<0.05), respectively, than in case of hypertension. Increase of spontaneous and stimulated ketone phenylhydrazone has also been observed in the main group. In case of psoriasis without essential hypertension the considered indicators exceed the respective values of persons with essential hypertension by 123 and 64.16 % (p<0.05), respectively, with the presence of essential hypertension -the difference with essential hypertension was only 67.83 and 28.32 % (p<0.05), respectively. So, patients with psoriasis and essential hypertension had more obvious changes of indicators stipulating the progressive increase of carbonyl stress processes.Conclusions. Thus, patients with combined pathology -psoriasis and essential hypertension -have development of oxidative and carbonyl stresses which signifi cantly shift thiol-disulfi de balance toward oxidized thiols.Obtained results showed the activation of oxidative stress in case of the studied comorbid pathology and also complex and ambiguous system of regulation of pro-and antioxidant balance which are presented by increase of free-radical oxidation activity and decrease of physiological antioxidant defence.Стан вільно-радикальних процесів і параметрів антиоксидантного захисту в пацієнтів, які хворі на псоріаз у поєднанні з гіпертонічною хворобою В. А. Візір, Г. І. Макуріна Мета роботи -вивчення стану вільно-радикальних процесів і параметрів антиоксидантного захисту у хворих на псоріаз із супут-ньою гіпертонічною хворобою.Матеріали та методи. Вивчили оксидативний стан у 95 пацієнтів, які були поділені на 3 групи: І -псоріаз і гіпертонічна хвороба (25 осіб); ІІ група -пацієнти лише із псоріазом (30 осіб) і III група -пацієнти лише з гіпертонічною хворобою (40 осіб). Для оціню-вання тяжкості ураження шкіри при псоріазі використовували Psoriasis Area and Severity Index (PASI). Визначення маркерів окисної деструкції білків -альдегідфенілгідразонів та кетонфенілгідразонів -здійснювали за методом B. Halliwell...

Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.