The therapeutic effects of chamomilla tincture mouthwash on oral aphthae: A Randomized Clinical Trial

“…An MTC mouthwash was effective in treating recurrent aphthous stomatitis (12) and oral mucositis (13). In addition, an MTC mouthwash reduced plaque accumulation and gingival inflammation, without significant effects on tooth staining, when used twice a day for 4 weeks (14).…”

“…In these cases, it may be useful, if not essential, to adopt an alternative therapy. In this scenario, phytotherapy has been adopted as a therapeutic alternative to alleviate symptoms and improve OLP patients’ quality of life; it also offers the advantages of low cost, availability and absence of adverse effects …”

“…A variety of approaches have been used to treat oral lichen planus (OLP) including corticosteroids, retinoids, topical cyclosporine, antimicrobials azathioprine, calcineurin inhibitors and surgery .The main disadvantage of these treatments are their secondary effects . Several studies have investigated the application of chamomile for treating different oral diseases, particularly gingivitis, mucositis, aphthous stomatitis, but most were not randomized, controlled trials for the application of chamomile to treat OLP patients . The purpose of this study was to compare the clinical therapeutic efficacy of topical applications of chamomile for treating OLP vs. a placebo.…”

“…Camazulene has a dose‐dependent anti‐inflammatory effect; it inhibits leukotriene B4 synthesis, and the peroxidation of arachidonic acid in neutrophils . Chamomile mouth rinse is prescribed for aphthous lesions, gingivitis, laryngitis, and oral mucositis . It has also been widely used to treat periodontal diseases; Pourabbas et al and Batista et al observed reductions in gingival bleeding as a result of its application.…”