doi: 10.1128/AAC.43.2.403.
Mycobacteriocidal action of exogenous nitric oxide
Affiliations
- PMID: 9925545
- PMCID: PMC89090
- DOI: 10.1128/AAC.43.2.403
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Mycobacteriocidal action of exogenous nitric oxide
Antimicrob Agents Chemother.
1999 Feb.
Abstract
We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (< 100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.
Figures
Exposure chamber and NO delivery system.
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