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. 1999 Feb;43(2):403-5.
doi: 10.1128/AAC.43.2.403.

Mycobacteriocidal action of exogenous nitric oxide

R Long  1 , B Light, J A Talbot
Affiliations

Mycobacteriocidal action of exogenous nitric oxide

R Long et al. Antimicrob Agents Chemother. 1999 Feb.

Abstract

We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (< 100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.

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Figures

FIG. 1
FIG. 1
Exposure chamber and NO delivery system.
See this image and copyright information in PMC

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