Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
- PMID: 9877175
- DOI: 10.1016/s0014-5793(98)01514-2
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
Abstract
The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-beta gene expression. Here we show that another member IRF-7 is critical for the IFN-alpha gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but not IRF-3 can rescue the deficiency to induce IFN-alpha genes. These results indicate that IRF-7 is a key factor in the positive feedback regulation of IFN-alpha/beta production.
Similar articles
-
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.Genes Cells. 1996 Jan;1(1):115-24. doi: 10.1046/j.1365-2443.1996.08008.x. Genes Cells. 1996. PMID: 9078371
-
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).J Biochem. 1996 Jul;120(1):160-9. doi: 10.1093/oxfordjournals.jbchem.a021379. J Biochem. 1996. PMID: 8864859
-
Regulation of IFN-alpha/beta genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN-alpha/beta.Genes Cells. 1996 Nov;1(11):995-1005. doi: 10.1046/j.1365-2443.1996.870287.x. Genes Cells. 1996. PMID: 9077462
-
Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.J Interferon Cytokine Res. 2002 Jan;22(1):87-93. doi: 10.1089/107999002753452692. J Interferon Cytokine Res. 2002. PMID: 11846979 Review.
-
The growing family of interferon regulatory factors.Cytokine Growth Factor Rev. 1997 Dec;8(4):293-312. doi: 10.1016/s1359-6101(97)00019-1. Cytokine Growth Factor Rev. 1997. PMID: 9620643 Review.
Cited by
-
A single-amino-acid polymorphism in reovirus protein μ2 determines repression of interferon signaling and modulates myocarditis.J Virol. 2012 Feb;86(4):2302-11. doi: 10.1128/JVI.06236-11. Epub 2011 Dec 7. J Virol. 2012. PMID: 22156521 Free PMC article.
-
Pellino1 is required for interferon production by viral double-stranded RNA.J Biol Chem. 2012 Oct 5;287(41):34825-35. doi: 10.1074/jbc.M112.367557. Epub 2012 Aug 17. J Biol Chem. 2012. PMID: 22902624 Free PMC article.
-
Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells.Am J Respir Cell Mol Biol. 2013 Nov;49(5):855-65. doi: 10.1165/rcmb.2013-0003OC. Am J Respir Cell Mol Biol. 2013. PMID: 23786562 Free PMC article.
-
Regulation of IRF7 through cell type-specific protein stability.Biochem Biophys Res Commun. 2006 Mar 31;342(1):50-6. doi: 10.1016/j.bbrc.2006.01.122. Epub 2006 Feb 3. Biochem Biophys Res Commun. 2006. PMID: 16472772 Free PMC article.
-
Type 1 interferons and myositis.Arthritis Res Ther. 2010;12 Suppl 1(Suppl 1):S4. doi: 10.1186/ar2885. Epub 2010 Apr 14. Arthritis Res Ther. 2010. PMID: 20392291 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
