Case Reports
doi: 10.1093/bja/81.3.468.
Adrenal failure in the critically ill
Affiliations
- PMID: 9861142
- DOI: 10.1093/bja/81.3.468
Item in Clipboard
Case Reports
Adrenal failure in the critically ill
Br J Anaesth.
1998 Sep.
Free article
Abstract
Three critically ill patients suffered multiple organ failure secondary to sepsis. Despite adequate supportive therapy and appropriate antibiotic cover, they failed to improve and required inappropriate inotrope support. They had not been treated with steroids or other drugs known to suppress adrenal function. Adrenal insufficiency was suspected. A random cortisol concentration and a short synacthen test demonstrated concentrations below the range expected in all three cases. High-dose steroid therapy was commenced with marked improvement in the short-term. However, in each case sepsis eventually caused death.
Comment in
-
Adrenocortical function in critical illness.Br J Anaesth. 1998 Sep;81(3):308-10. doi: 10.1093/bja/81.3.308. Br J Anaesth. 1998. PMID: 9861109 No abstract available.
-
Adrenal failure in the critically ill.Br J Anaesth. 1999 Jan;82(1):152-3. doi: 10.1093/bja/82.1.152. Br J Anaesth. 1999. PMID: 10325858 No abstract available.
Similar articles
-
Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock.Hepatology. 2006 Apr;43(4):673-81. doi: 10.1002/hep.21101. Hepatology. 2006. PMID: 16557538
-
[Relative adrenocortical insufficiency with sepsis, diagnosed and treated with hydrocortisone supplementation].Ned Tijdschr Geneeskd. 2001 Sep 8;145(36):1749-51. Ned Tijdschr Geneeskd. 2001. PMID: 11572177 Dutch.
-
Hydrocortisone Therapy in Catecholamine-Resistant Pediatric Septic Shock: A Pragmatic Analysis of Clinician Practice and Association With Outcomes.Pediatr Crit Care Med. 2017 Sep;18(9):e406-e414. doi: 10.1097/PCC.0000000000001237. Pediatr Crit Care Med. 2017. PMID: 28658197 Free PMC article.
-
Relative adrenal insufficiency in a patient with liver disease.Eur J Gastroenterol Hepatol. 2009 Apr;21(4):381-3. doi: 10.1097/MEG.0b013e328309c77e. Eur J Gastroenterol Hepatol. 2009. PMID: 20611008 Review.
-
Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.Intensive Care Med. 2017 Dec;43(12):1751-1763. doi: 10.1007/s00134-017-4919-5. Epub 2017 Sep 21. Intensive Care Med. 2017. PMID: 28940011
Cited by
-
Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?Crit Care. 2015 Nov 27;19:418. doi: 10.1186/s13054-015-1131-2. Crit Care. 2015. PMID: 26612352 Free PMC article.
-
Metabolic changes after polytrauma: an imperative for early nutritional support.World J Emerg Surg. 2006 Oct 4;1:29. doi: 10.1186/1749-7922-1-29. World J Emerg Surg. 2006. PMID: 17020610 Free PMC article.
-
What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?Arch Dis Child. 2007 Feb;92(2):165-9. doi: 10.1136/adc.2005.088450. Epub 2006 Sep 26. Arch Dis Child. 2007. PMID: 17003064 Free PMC article. Review.
-
Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock.J Res Pharm Pract. 2016 Apr-Jun;5(2):94-100. doi: 10.4103/2279-042X.179569. J Res Pharm Pract. 2016. PMID: 27162802 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
