doi: 10.1126/science.282.5392.1281.
An essential role for ectodomain shedding in mammalian development
Affiliations
- PMID: 9812885
- DOI: 10.1126/science.282.5392.1281
Item in Clipboard
An essential role for ectodomain shedding in mammalian development
Science.
.
Abstract
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Comment in
-
A cellular striptease act.Science. 1998 Nov 13;282(5392):1279-80. doi: 10.1126/science.282.5392.1279. Science. 1998. PMID: 9867633 No abstract available.
Similar articles
-
The transmembrane domain of TACE regulates protein ectodomain shedding.Cell Res. 2007 Dec;17(12):985-98. doi: 10.1038/cr.2007.98. Cell Res. 2007. PMID: 18040288
-
Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE).J Biol Chem. 2004 Jun 25;279(26):27365-75. doi: 10.1074/jbc.M401690200. Epub 2004 Apr 9. J Biol Chem. 2004. PMID: 15075334
-
Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.Dev Biol. 2001 Apr 1;232(1):204-18. doi: 10.1006/dbio.2001.0176. Dev Biol. 2001. PMID: 11254358
-
TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.Ann N Y Acad Sci. 2003 May;995:22-38. doi: 10.1111/j.1749-6632.2003.tb03207.x. Ann N Y Acad Sci. 2003. PMID: 12814936 Review.
-
A brief history of tumor necrosis factor α--converting enzyme: an overview of ectodomain shedding.Keio J Med. 2013;62(1):29-36. doi: 10.2302/kjm.2012-0003-re. Keio J Med. 2013. PMID: 23563789 Review.
Cited by
-
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.Science. 2012 Jan 13;335(6065):225-8. doi: 10.1126/science.1214400. Science. 2012. PMID: 22246777 Free PMC article.
-
Adoptive Transfer of Engineered Rhesus Simian Immunodeficiency Virus-Specific CD8+ T Cells Reduces the Number of Transmitted/Founder Viruses Established in Rhesus Macaques.J Virol. 2016 Oct 14;90(21):9942-9952. doi: 10.1128/JVI.01522-16. Print 2016 Nov 1. J Virol. 2016. PMID: 27558423 Free PMC article.
-
Phosphatidylserine exposure is required for ADAM17 sheddase function.Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523. Nat Commun. 2016. PMID: 27161080 Free PMC article.
-
Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites.J Biol Chem. 2012 Feb 10;287(7):4581-9. doi: 10.1074/jbc.M111.321182. Epub 2011 Dec 14. J Biol Chem. 2012. PMID: 22170060 Free PMC article.
-
Human cytomegalovirus pUL10 interacts with leukocytes and impairs TCR-mediated T-cell activation.Immunol Cell Biol. 2016 Oct;94(9):849-860. doi: 10.1038/icb.2016.49. Epub 2016 May 19. Immunol Cell Biol. 2016. PMID: 27192938
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
