Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis
- PMID: 9800110
- DOI: 10.1097/00001622-199809000-00007
Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis
Abstract
Seroepidemiologic studies show that Kaposi's sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi's sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission appear to be more important in Africa and Mediterranean Europe. KSHV encodes numerous cellular homologues that might be involved in KS and lymphoma pathogenesis. The characterization of these homologues provides insight into the functions of their cellular counterparts. KSHV is also unique among human herpesviruses by encoding chemokine homologues. Unlike cellular MIP1 alpha and RANTES, KSHV-chemokines are promiscuous in their receptor usage and do induce angiogenesis. They may also play a role in preventing central nervous system diseases in HIV-positive individuals.
Similar articles
-
A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma.Nat Med. 1995 Jul;1(7):707-8. doi: 10.1038/nm0795-707. Nat Med. 1995. PMID: 7585156
-
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.J Antimicrob Chemother. 2000 Apr;45 Suppl T3:15-27. doi: 10.1093/jac/45.suppl_4.15. J Antimicrob Chemother. 2000. PMID: 10855768 Review.
-
Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk.Curr Opin Oncol. 1999 Nov;11(6):508-15. doi: 10.1097/00001622-199911000-00013. Curr Opin Oncol. 1999. PMID: 10550016
-
Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients.Blood. 1997 Oct 1;90(7):2826-9. Blood. 1997. PMID: 9326251
-
Molecular studies and therapeutic targeting of Kaposi's sarcoma herpesvirus (KSHV/HHV-8) oncogenesis.Immunol Res. 2013 Dec;57(1-3):159-65. doi: 10.1007/s12026-013-8458-z. Immunol Res. 2013. PMID: 24203444 Free PMC article. Review.
Cited by
-
Chronic immune activation and inflammation as the cause of malignancy.Br J Cancer. 2001 Aug 17;85(4):473-83. doi: 10.1054/bjoc.2001.1943. Br J Cancer. 2001. PMID: 11506482 Free PMC article. Review.
-
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.J Mol Med (Berl). 2004 Apr;82(4):223-31. doi: 10.1007/s00109-003-0519-7. Epub 2004 Jan 9. J Mol Med (Berl). 2004. PMID: 14991150 Review.
-
Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda.Trop Med Int Health. 2015 May;20(5):665-672. doi: 10.1111/tmi.12464. Epub 2015 Feb 9. Trop Med Int Health. 2015. PMID: 25611008 Free PMC article.
-
Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus.J Virol. 2001 Feb;75(4):1857-63. doi: 10.1128/JVI.75.4.1857-1863.2001. J Virol. 2001. PMID: 11160684 Free PMC article.
-
Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions.Int J Cancer. 2007 Jan 15;120(2):321-8. doi: 10.1002/ijc.22205. Int J Cancer. 2007. PMID: 17066452 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical